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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03081637
Other study ID # FLNA in HCC
Secondary ID
Status Completed
Phase N/A
First received March 2, 2017
Last updated May 31, 2017
Start date January 1, 2004
Est. completion date March 2, 2017

Study information

Verified date May 2017
Source University of Milan
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The risk of recurrence after hepatectomy for hepatocellular carcinoma (HCC) is very high. Having a predictive marker of early recurrence (ER) would be desirable to personalize the follow-up and possibly develop new targeted therapy. The aim of this study was to test the expression of Filamin A (FLNA) in a cohort of patients operated for HCC.


Description:

A consecutive cohort of resected HCC patients will be analyzed. Several different prognostic factors, including FLNA expression, will be tested against the risk of ER. FLNA expression will be analyzed with immunohistochemistry in the intra-tumoral and extra-tumoral tissue compartments using a dedicated tissue microarray.


Recruitment information / eligibility

Status Completed
Enrollment 115
Est. completion date March 2, 2017
Est. primary completion date December 31, 2014
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- The inclusion criteria were represented by the histological positivity for HCC with complete clinical, surgical, pathological, and follow-up data.

Exclusion Criteria:

- Patients preoperatively treated with chemotherapy or trans-arterial therapy were excluded.

- Similarly, patients operated for recurrent HCC or with non-radical surgery or with missing data were excluded.

Study Design


Related Conditions & MeSH terms


Locations

Country Name City State
n/a

Sponsors (1)

Lead Sponsor Collaborator
University of Milan

Outcome

Type Measure Description Time frame Safety issue
Primary Rate of expression of Filamin A (FLNA) in HCC specimens from patients resected for HCC. The rate of expression of FLNA in HCC specimens will be measured using standard immunohistochemistry methodology on surgical specimens. Such expression rate will be correlated to several different clinical and pathological parameters. 2 years after surgery as a minimum follow-up
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