HELLP Syndrome Clinical Trial
Official title:
Assessment of Immature Platelet Fraction in Pregnancy-Associated Thrombotic Microangiopathy
Immature platelet fraction is a non-invasive test of real time thrombopoiesis. High IPF% has been suggested as an indicator of thrombocytopenia due to rapid platelet consumption. IPF% is able to discriminate between patients with TTP/HUS or SPE/HELLP
Thrombotic microangiopathy (TMA) syndromes are extraordinarily diverse. Thrombotic
thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are the two most well
known, and are considered to be the most serious. TTP-HUS occurs more commonly in women and
among women is commonly associated with pregnancy.
Nevertheless, there are other pregnancy conditions that may manifest with TMA, including
preeclampsia, eclampsia, HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet
count), in addition to acute fatty liver of pregnancy, antiphospholipid syndrome, and
systemic lupus erythematosis.
Assessment of immature platelets was introduced as a non-invasive test of real time
thrombopoiesis. They are newly released in the circulation with a larger size & greater RNA
content than mature platelets, and can be measured by automated haematology analyzer equipped
with reticulocyte detection channel and described as immature platelet fraction (%-IPF) and
immature platelet count (A-IPC).
A high %-IPF has been suggested as an indicator of thrombocytopenia due to rapid platelet
consumption, while a low %-IPF is characteristic of bone marrow suppression states.
%-IPF/A-IPF has the competency to be performed routinely and, therefore, can provide
therapeutic and diagnostic feedback in the life threatening conditions.
The present study aimed to show the utility of estimating %-IPF and A-IPC using a
reticulocyte detection channel CBC autoanalyzer as a simple reproducible blood analysis to be
employed in the differential diagnosis of pregnancy-associated thrombotic microangiopathic
conditions.
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