IMAGE-HF: Project IIa Canadian CArdiomyopathy Registry for Device Therapy

Heart Failure Clinical Trial

— CanCARD-MR  

Official title:

IMAGE-HF: Project IIa - Canadian CArdiomyopathy Registry for Device Therapy (CanCARD-MR)

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT04908306
• Other study ID #: 2011308-01
• Status: Active, not recruiting
• Start date: October 11, 2011
• Est. completion date: August 1, 2023

Study information

• Verified date: February 2023
• Source: Ottawa Heart Institute Research Corporation
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Delayed enhanced MRI in patients (of either ischemic or non-ischemic cause) being referred for primary prevention ICD

Description:

Device therapy using defibrillators and cardiac resynchronization therapy (CRT) is an important advance in the care of patients with acquired heart disease and heart failure. In specific groups these devices appear to significantly reduce the risk of sudden cardiac death and progression of heart failure. However, our ability to identify ideal candidates, and those who are most likely to respond and benefit from this therapy, is poor. Preliminary studies using specialized Magnetic Resonance Imaging (MRI) appears to be one of the more valuable ways of predicting response to device therapy and holds substantial promise for patients with cardiomyopathy. Large, prospective registries are necessary to explore its real-world utility for risk prediction across a broad spectrum of patients. Can-CARD MR is a national, multi-centre registry designed to address this particular need.

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 502
• Est. completion date: August 1, 2023
• Est. primary completion date: August 1, 2023
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• .Any patient accepted for primary prevention ICD (+/-) CRT)

Exclusion Criteria:

• Known contra-indications to MRI.
• Recent myocardial infarction or revascularization procedure within the past 3 months.
• GFR (glomerular filtration rate) = 30 ml. / min/ m2.

Related Conditions & MeSH terms

• Cardiomyopathies
• Heart Failure

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Ottawa Heart Institute Research Corporation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Occurrence of a)appropriate ICD therapy (shock or anti-tachycardia pacing (ATP)) or sudden cardiac death	Occurrence of a)appropriate ICD therapy (shock or anti-tachycardia pacing (ATP)) or sudden cardiac death	1 year