Novel Risk Factors of Atrial Fibrillation in Patients With Chronic Heart Failure

Heart Failure Clinical Trial

Official title:

Study to Evaluate Association of Blood Lipid Levels With Atrial Fibrillation Incidence in Patients With Chronic Heart Failure

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT02655185
• Other study ID #: 2016003
• Status: Not yet recruiting
• Phase: N/A
• First received: January 10, 2016
• Last updated: January 11, 2016
• Start date: February 2016
• Est. completion date: July 2019

Study information

• Verified date: January 2016
• Source: Yangzhou No.1 People's Hospital
• Contact: Chen - Liu, MD
• Phone: +86-13301457671
• Email: liuchen007[@]163.com
• Is FDA regulated: No
• Health authority: China: Ethics Committee
• Study type: Observational

Clinical Trial Summary

The purpose of this study is to determine whether lipid levels are related with incidence of atrial fibrillation in Patients with chronic heart failure.

Description:

Atrial fibrillation (AF) is the most common cardiac arrhythmia in clinical practice. Chronic Heart failure (CHF) has become a major clinical and public health problem. Both AF and CHF often co-exist and complicate each other's administration.Several risk factors have been demonstrated to be associated with the risk of AF in Patients with CHF.

Lopez et al. found that higher levels of low-density lipoprotein cholesterol (LDLc) and total cholesterol were associated with a lower incidence of AF independently of other risk factors from the Atherosclerosis Risk in Communities (ARIC) study.

Thus the purpose of this study is to determine whether lipid levels are related with incidence of atrial fibrillation in Patients with chronic heart failure. This study maybe provide a novel opinion on the prevention of AF in patients with CHF.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 300
• Est. completion date: July 2019
• Est. primary completion date: July 2018
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 40 Years to 90 Years

Eligibility

Inclusion Criteria:

• Clinical diagnosis of chronic heart failure

Exclusion Criteria:

• Use of statins

Study Design

Observational Model: Cohort, Time Perspective: Retrospective

Related Conditions & MeSH terms

• Atrial Fibrillation
• Heart Failure

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Yangzhou No.1 People's Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Number of participants with newly emerging atrial fibrillation as assessed by electrocardiogram		three years	No
Secondary	Cardiovascular mortality		three years	No
Secondary	Worsing heart failure assessed by decreased NYHA class and left ventricular ejection fraction		three years	No
Secondary	rate of rehospitalization		three years	No