Heart Failure Clinical Trial
Official title:
The Effect of Stair Descending and Stair Ascending Exercise on Muscle Strength and Performance: the SmartEscalator Device
Verified date | August 2012 |
Source | European University Cyprus |
Contact | n/a |
Is FDA regulated | No |
Health authority | Cyprus: Ministry of Health |
Study type | Interventional |
The aim of the present project is to compare the acute and chronic effect of stair descending versus stair ascending exercise on muscle damage and performance in elderly males with chronic heart failure.
Status | Completed |
Enrollment | 12 |
Est. completion date | April 2012 |
Est. primary completion date | April 2012 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | 60 Years to 70 Years |
Eligibility |
Inclusion Criteria: - chronic heart failure (New York Heart Association class I-II) - subject provides written informed consent - personal physician of the participants provides written informed consent Exclusion Criteria: - smoker - consumed any nutritional supplement the last 3 months - performed intense eccentric exercise the last 6 months - non Caucasian |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Cyprus | European University Cyprus | Nicosia |
Lead Sponsor | Collaborator |
---|---|
European University Cyprus | Aristotle University Of Thessaloniki, University of Thessaly |
Cyprus,
Paschalis V, Nikolaidis MG, Theodorou AA, Panayiotou G, Fatouros IG, Koutedakis Y, Jamurtas AZ. A weekly bout of eccentric exercise is sufficient to induce health-promoting effects. Med Sci Sports Exerc. 2011 Jan;43(1):64-73. doi: 10.1249/MSS.0b013e3181e91d90. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Muscle strength (torque) | An isokinetic dynamometer (Cybex, Ronkonkoma, NY) will be used for the measurement of isometric, eccentric and concentric knee extensor peak torque at 90° knee flexion. The average of the three best maximal voluntary contractions with their dominant leg will be recorded. In order to ensure that the subjects provide their maximal effort, the measurements will be repeated if the difference between the lower and the higher torque value exceeded 10%. There will be two minutes rest between isometric efforts. | Change from baseline in muscle strength at day 2 post exercise at the first and sixth week of training | No |
Secondary | Pain free range of motion (degrees) | The assessment of pain-free ROM will be performed manually using the the isokinetic dynamometer. The investigator will move the calf at a very low angular velocity from 0 knee extension to the position where the subject will feel any discomfort. | Before and at day 2 post exercise at the first and sixth week of training | No |
Secondary | Creatine kinase, CK (activity IU) | CK activity will be measured as a general indicator of muscle damage.It will be measured in a Cobas Integra Plus 400 chemistry analyzer. | Before and at day 2 post exercise at the first and sixth week of training | No |
Secondary | Delayed onset muscle soreness, DOMS (scale 1-10) | Each participant will assess delayed onset muscle soreness (DOMS) during squat movement (90o knee flexion) and perceived soreness will be rated on a scale ranging from 1 (normal) to 10 (very sore). | Before and at day 2 post exercise at the first and sixth week of training | No |
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