Heart Failure Clinical Trial
Official title:
The Influence of Sunitinib on Contractility of Human Atrial Trabeculae
Rationale:
Recently, sunitinib (a tyrosine kinase inhibitor that is used for treatment of metastatic
renal carcinoma and gastrointestinal stroma tumors) has been associated with development of
heart failure, possibly by off-target inhibition of AMP-protein kinase. The investigators
hypothesize that sunitinib reduces the contractile ability of myocardium and the tolerance
against ischemia-reperfusion and that activators of AMP-protein kinase such as atorvastatin
and AICAR reverse this unwanted effect of sunitinib.
Objectives:
The primary objective of the study is to investigate the effect of sunitinib on ex-vivo
atrial contractile force in absence and presence of ischemia-reperfusion.
A secondary objective is to explore if atorvastatin or AICAR prevent sunitinib-induced
deterioration of contractile function of human atrial trabeculas. Study design: Lab
Study population: 44 (+22) patients undergoing CABG cardiac surgery with extracorporal circulation Intervention (if applicable): none (pharmacological interventions will only be performed ex-vivo in isolated atrial tissue) Main study parameters/endpoints The developed force in ex vivo atrial trabeculas during standardized stimulation. ;
Observational Model: Case-Only
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