Effect of Aldosterone on Energy Starvation in Heart Failure

Status Completed

Clinical Trial Summary

We plan to study the concept of "energy starvation" in heart failure by evaluation of patients with nonischemic dilated cardiomyopathy (NIDCM) (heart failure with reduced heart pump function due to causes other than heart attack). We will use a combination of positron emission tomography and magnetic resonance imaging to study metabolism, anatomy, function, blood flow and efficiency, before and after 6 months' treatment with the drug spironolactone which blocks the deleterious effects of the hormone aldosterone on the myocardium (heart muscle).

Clinical Trial Description

Preliminary results showed reduced subendocardial myocardial perfusion reserve in NIDCM compared to normal subjects, and that the degree of impaired perfusion reserve was related to the oxidative metabolic rate as measured by positron emission tomography. ;

Study Design

Related Conditions & MeSH terms

Cardiomyopathies
Cardiomyopathy, Dilated
Heart Failure
Nonischemic Dilated Cardiomyopathy
Starvation

Clinical Trial Details

NCT number	NCT00574119
Study type	Interventional
Source	Vanderbilt University Medical Center
Contact
Status	Completed
Phase	Phase 4
Start date	December 2007
Completion date	July 2012

View Details

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