Heart Failure Clinical Trial
Official title:
PD-HF: A Multi-centre Randomised Controlled Trial of Intermittent Peritoneal Dialysis With Icodextrin-based Solutions on Patients With Severe Heart Failure and Stage 3-4 Chronic Kidney Disease
This trial is to establish whether ultrafiltration by peritoneal dialysis is a clinically effective treatment for patients with severe heart failure and moderate chronic kidney disease, thus improving quality of life and symptoms.
The trial is a multi-centre, prospective, randomised, unblended, controlled trial of
intermittent PD with a single daily exchange of icodextrin plus best standard care versus
best standard care for the treatment of severe HF and moderate CKD. A second exchange with
glucose based solution may be given, should it be required in the investigator's/clinician's
opinion. Investigators will randomise 130 participants for 32 weeks with randomisation
stratified by participating centre. Participants will be recruited from specialist-led
outpatient HF services in 6 NHS trusts and be managed by both cardiologists and
nephrologists.
PD catheter insertion will occur according to the participating centre's institutional
protocol. Treatment begins 1 week after catheter insertion and consists of a single nightly
exchange.
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