Ventricular-Vascular Coupling in Heart Failure

Heart Failure With Preserved Ejection Fraction Clinical Trial

Official title: Ventricular-Vascular Coupling in Patients With Heart Failure and Preserved Ejection Fraction

Status Completed

Clinical Trial Summary

This study will test the hypothesis that increases in ventricular-vascular stiffness can be demonstrated by arterial tonometry and echocardiography in subjects with heart failure with preserved ejection fraction (HF-nlEF)(i.e. normal left ventricular function.) We will also track changes in pulsatile hemodynamics over time in subjects hospitalized with HF-nlEF.

Clinical Trial Description

The pathophysiologic mechanisms responsible for the development of heart failure in people with preserved ejection fraction (i.e. normal left ventricular function) remain poorly understood. One possible mechanism may be the contribution of increased arterial stiffness to changes in pulsatile hemodynamic load during ventricular systole, implicating abnormal ventricular-vascular interactions throughout the cardiac cycle in the pathogenesis of heart failure with normal ejection fraction.

To investigate changes in ventricular-vascular stiffness in subjects with heart failure and normal left ventricular function, comparisons will be made between 3 distinct sub-populations:

• subjects with heart failure and normal ejection fraction

• non-diabetic hypertensive controls

• normotensive controls ;

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Heart Failure
• Heart Failure With Preserved Ejection Fraction

• NCT number: NCT00207220
• Study type: Observational
• Source: Brigham and Women's Hospital
• Status: Completed
• Phase: N/A
• Start date: January 2004
• Completion date: January 2007