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NCT00190359 Clinical Trial

Growth Hormone and Heart Failure

Heart Failure, Congestive Clinical Trial

Official title:
Modifications of the Growth Hormone/IGF1 Axis in Heart Failure Patients

Clinical Trial Details — Status: Terminated

Administrative data
NCT number NCT00190359
Other study ID # CRC00007
Secondary ID
Status Terminated
Phase N/A
First received September 14, 2005
Last updated September 14, 2005
Start date September 2000
Est. completion date February 2003

Study information
Verified date April 2002
Source Assistance Publique - Hôpitaux de Paris
Contact n/a
Is FDA regulated No
Health authority France: Ministry of Health
Study type Observational

Clinical Trial Summary

Heart failure induces modification in several neurohormonal systems. The aim of this study is to determine if the growth hormone/IGF1 axis is modified in heart failure patients compared to healthy volunteers.

Description:

One hundred and sixty three heart failure patients were evaluated by clinical examination, echocardiography, exercise test and measurement of blood BNP. Growth hormone and IGF-1 plasma levels were determined in each patient. The same biological measurements were performed in a group of 148 healthy controls. Comparisons were performed between groups for Growth hormone plasma level, IGF-1 plasma level and Growth hormone/IGF-1 index. A correlation between the severity of heart failure and the different biological parameters was searched.

Recruitment information / eligibility
Status Terminated
Enrollment 180
Est. completion date February 2003
Est. primary completion date
Accepts healthy volunteers No
Gender Both
Age group 18 Years and older
Eligibility Inclusion Criteria:

- Heart failure patients in stable condition

Exclusion Criteria:

- cancer

- pituitary disease

Study Design

Observational Model: Case Control, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Assistance Publique - Hôpitaux de Paris
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