Heart Diseases Clinical Trial
A detailed review was made of data pertinent to the occurrence of chronic Chagas disease in the United States.
BACKGROUND:
In Latin America, 16 to 18 million individuals are thought to have Chagas' disease and 90
million are considered to be at risk of infection. In the United States, the occurrence of
Chagas' disease is virtually limited to individuals who have resided in Latin America where
they acquired the infection, and then migrated to this country.
DESIGN NARRATIVE:
Data on the prevalence of positive serologic reactions for Trypanosoma cruzi (a protozoan
causing Chagas cardiomyopathy) serve for calculating that a total of up to 74,000 Latin
Americans residing in the United States have the chronic form of chagasic cardiomyopathy.
The vast majority of these individuals are either undiagnosed, or misdiagnosed as having
idiopathic dilated cardiomyopathy or coronary artery disease. Vector transmission of T.
cruzi infection is very unlikely to occur in the United States because of variations in
biological behavior of local species of insect vectors and because of changes in human
living conditions. Transfusion of blood from infected but asymptomatic individuals is
considered the most important mechanism of transmission of this disorder in the United
States.
The study completion date listed in this record was obtained from the "End Date" entered in
the Protocol Registration and Results System (PRS) record.
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|---|---|---|---|
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