Heart Disease Clinical Trial
Official title:
Investigating the Interaction of Apelin and Angiotensin II Peripheral Resistance Vessels in Vivo in Man
Verified date | May 2009 |
Source | University of Edinburgh |
Contact | n/a |
Is FDA regulated | No |
Health authority | United Kingdom: Research Ethics Committee |
Study type | Interventional |
The apelin-APJ system is a relatively new discovery. It has generated interest in part due
to it's apparent ability to counteract the renin-angiotensin system, which is frequently
overactive in many cardiovascular disease.
Apelin has the ability to cause blood vessels to relax, increasing their diameter and hence
blood flow down the blood vessel. The researchers wish to investigate the hypothesis that an
infusion of apelin will reduce the effects of angiotensin II, which is know to reduce the
diameter of blood vessels.
Status | Completed |
Enrollment | 12 |
Est. completion date | April 2010 |
Est. primary completion date | April 2010 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 18 Years to 85 Years |
Eligibility |
Inclusion Criteria: - > 18 years old - Healthy volunteers Exclusion Criteria: - Lack of informed consent - Age < 18 years, - Current involvement in other research studies, - Systolic blood pressure >190 mmHg or <100 mmHg - Malignant arrhythmias - Renal or hepatic failure - Haemodynamically significant aortic stenosis - Severe or significant co morbidity - Women of childbearing potential. - Any regular medication - Previous history of any cardiovascular disease |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
Country | Name | City | State |
---|---|---|---|
United Kingdom | Clincial Research Facility, Royal Infirmary of Edinburgh, 51 Little France Cresc | Edinburgh |
Lead Sponsor | Collaborator |
---|---|
University of Edinburgh |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in angiotensin II mediated vasoconstriction | 12 months | No | |
Secondary | Changes in relevant neurohumoral hormones in response to apelin infusion | 12 months | No |
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