Clinical Trials Logo

Clinical Trial Summary

Endpoint implementation of reactions initiated by ischemia is the mitochondrial transition pore permeability. Mitochondria pores opening results in a release of factors triggering apoptosis primarily the cytochrome С Inhibition of the pores opening protects ischemic damage of the cells. The key enzyme regulating the mitochondrial permeability transition pore is GSK-3b: the phosphorylation of the enzyme inactivates the enzyme and prevents pore opening. Aim of studi is to determine content of the phosphorylatcd GS K-3b in neurons of rat brain in the model of total tschemia/reperfusion.


Clinical Trial Description

Endpoint implementation of reactions initiated by ischemia is the mitochondrial transition pore permeability. Mitochondria pores opening results in a release of factors triggering apoptosis. primarily the cytochrome С Inhibition of the pores opening protects ischemic damage of the cells. The key enzyme regulating the mitochondrial permeability transition pore is glycogen synthase-kinase 3b (GSK-3b): the phosphorylation of the enzyme inactivates the enzyme and prevents pore opening. We have shown in previous study that preconditioning with sevoflurane increases the content of the phosphorylated form of 6SK-3b and protects the mitochondria of neurons in rats brain during ischemia/reperfusion. Aim of studi is to determine content of the phosphorylated GS K-3b in neurons of rat brain in the model of total ischemia/reperfusion influenced by: 1 MAC desflurane vs control group; 1 MAC desflurane vs 1 MAC sevoflurane and 1 MAC desflurane vs training ischemia. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04287842
Study type Interventional
Source Negovsky Reanimatology Research Institute
Contact
Status Withdrawn
Phase Phase 4
Start date May 2015
Completion date June 2015

See also
  Status Clinical Trial Phase
Completed NCT04078815 - End-of-life Practices in 2019 vs. 2014
Completed NCT02816385 - Study of Myocardial Contractility After Cardiac Surgery Under an Anterograde or Retrograde Cardioplegia N/A
Completed NCT02486211 - Amantadine to Speed Awakening After Cardiac Arrest Phase 2
Recruiting NCT02326506 - Evaluation of Drainable Volume Measurements During VA-ELS N/A
Completed NCT00139542 - AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute" Phase 3
Completed NCT00004560 - Public Access Defibrillation (PAD) Community Trial Phase 3
Completed NCT00000502 - Evaluation of SC-V Versus Conventional CPR Phase 3
Completed NCT03640949 - Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest Phase 2/Phase 3
Completed NCT03310450 - Tour de Borobudur Troponin Study on Predictors and Synergistic Role of MDA and Hs-CRP Levels
Completed NCT02733146 - Histones and Free-plasma DNA After Cardiac Arrest N/A
Withdrawn NCT01082991 - Patient Acuity Rating: a Tool to Prevent In-Hospital Cardiac Arrest Phase 0
Terminated NCT00189423 - ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest N/A
Completed NCT00172354 - Hydrocortisone in Patients of Out-of-hospital Cardiac Arrest N/A
Completed NCT02858583 - SI + CC Versus 3:1 C:V Ratio During Neonatal CPR N/A
Completed NCT03664557 - Feasibility of REBOA in Refractory Cardiac Arrest N/A
Completed NCT01968148 - Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest N/A
Completed NCT00392639 - Clinical and Economical Interest of Endovascular Cooling in the Management of Cardiac Arrest (ICEREA Study) Phase 4
Recruiting NCT06081283 - Antiseizure Medication in Seizure Networks at Early Acute Brain Injury Phase 4
Recruiting NCT05321459 - Predictive Outcome in Comatose Patients
Completed NCT02780050 - Influence of Core Muscles Activation Using Physical Fitness on the Performance of Chest Compression N/A