Heart Arrest Clinical Trial
Official title:
Neuroprotective Effect of Desflurane in the Experimental Study: the Impact if Desflurane Preconditioning on the Content of the Phosphorylated Form of GSK-3b in the Neurons of the Rat's Brain in the Model of Ischemia/Reperfusion
NCT number | NCT04287842 |
Other study ID # | Des-2014E |
Secondary ID | |
Status | Withdrawn |
Phase | Phase 4 |
First received | |
Last updated | |
Start date | May 2015 |
Est. completion date | June 2015 |
Verified date | February 2020 |
Source | Negovsky Reanimatology Research Institute |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Endpoint implementation of reactions initiated by ischemia is the mitochondrial transition pore permeability. Mitochondria pores opening results in a release of factors triggering apoptosis primarily the cytochrome С Inhibition of the pores opening protects ischemic damage of the cells. The key enzyme regulating the mitochondrial permeability transition pore is GSK-3b: the phosphorylation of the enzyme inactivates the enzyme and prevents pore opening. Aim of studi is to determine content of the phosphorylatcd GS K-3b in neurons of rat brain in the model of total tschemia/reperfusion.
Status | Withdrawn |
Enrollment | 0 |
Est. completion date | June 2015 |
Est. primary completion date | May 2015 |
Accepts healthy volunteers | No |
Gender | Male |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - breeding albino male rats weigh from 180 to 240 g Exclusion Criteria: - N/A |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Negovsky Reanimatology Research Institute |
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | total GSK-3b and phosphorilated (pGSK-3b) | after 15 minutes of exposition |
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
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