Heart Arrest Clinical Trial
Official title:
Neuroprotective Effect of Desflurane in the Experimental Study: the Impact if Desflurane Preconditioning on the Content of the Phosphorylated Form of GSK-3b in the Neurons of the Rat's Brain in the Model of Ischemia/Reperfusion
Endpoint implementation of reactions initiated by ischemia is the mitochondrial transition pore permeability. Mitochondria pores opening results in a release of factors triggering apoptosis primarily the cytochrome С Inhibition of the pores opening protects ischemic damage of the cells. The key enzyme regulating the mitochondrial permeability transition pore is GSK-3b: the phosphorylation of the enzyme inactivates the enzyme and prevents pore opening. Aim of studi is to determine content of the phosphorylatcd GS K-3b in neurons of rat brain in the model of total tschemia/reperfusion.
Endpoint implementation of reactions initiated by ischemia is the mitochondrial transition pore permeability. Mitochondria pores opening results in a release of factors triggering apoptosis. primarily the cytochrome С Inhibition of the pores opening protects ischemic damage of the cells. The key enzyme regulating the mitochondrial permeability transition pore is glycogen synthase-kinase 3b (GSK-3b): the phosphorylation of the enzyme inactivates the enzyme and prevents pore opening. We have shown in previous study that preconditioning with sevoflurane increases the content of the phosphorylated form of 6SK-3b and protects the mitochondria of neurons in rats brain during ischemia/reperfusion. Aim of studi is to determine content of the phosphorylated GS K-3b in neurons of rat brain in the model of total ischemia/reperfusion influenced by: 1 MAC desflurane vs control group; 1 MAC desflurane vs 1 MAC sevoflurane and 1 MAC desflurane vs training ischemia. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT04078815 -
End-of-life Practices in 2019 vs. 2014
|
||
| Completed |
NCT02816385 -
Study of Myocardial Contractility After Cardiac Surgery Under an Anterograde or Retrograde Cardioplegia
|
N/A | |
| Completed |
NCT02486211 -
Amantadine to Speed Awakening After Cardiac Arrest
|
Phase 2 | |
| Recruiting |
NCT02326506 -
Evaluation of Drainable Volume Measurements During VA-ELS
|
N/A | |
| Completed |
NCT00139542 -
AED Use in Out-of-Hospital Cardiac Arrest: A New Algorithm Named "One Shock Per Minute"
|
Phase 3 | |
| Completed |
NCT00004560 -
Public Access Defibrillation (PAD) Community Trial
|
Phase 3 | |
| Completed |
NCT00000502 -
Evaluation of SC-V Versus Conventional CPR
|
Phase 3 | |
| Completed |
NCT03640949 -
Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest
|
Phase 2/Phase 3 | |
| Completed |
NCT03310450 -
Tour de Borobudur Troponin Study on Predictors and Synergistic Role of MDA and Hs-CRP Levels
|
||
| Completed |
NCT02733146 -
Histones and Free-plasma DNA After Cardiac Arrest
|
N/A | |
| Withdrawn |
NCT01082991 -
Patient Acuity Rating: a Tool to Prevent In-Hospital Cardiac Arrest
|
Phase 0 | |
| Terminated |
NCT00189423 -
ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest
|
N/A | |
| Completed |
NCT00172354 -
Hydrocortisone in Patients of Out-of-hospital Cardiac Arrest
|
N/A | |
| Completed |
NCT02858583 -
SI + CC Versus 3:1 C:V Ratio During Neonatal CPR
|
N/A | |
| Completed |
NCT03664557 -
Feasibility of REBOA in Refractory Cardiac Arrest
|
N/A | |
| Completed |
NCT01968148 -
Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest
|
N/A | |
| Completed |
NCT00392639 -
Clinical and Economical Interest of Endovascular Cooling in the Management of Cardiac Arrest (ICEREA Study)
|
Phase 4 | |
| Recruiting |
NCT06081283 -
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
|
Phase 4 | |
| Recruiting |
NCT05321459 -
Predictive Outcome in Comatose Patients
|
||
| Completed |
NCT02780050 -
Influence of Core Muscles Activation Using Physical Fitness on the Performance of Chest Compression
|
N/A |