Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Short-term difference in ventilation defect percent assessed by ventilation SPECT-CT - healthy |
The short-term difference in lung ventilation between healthyCOVID-19+ and healthyCOVID-19- participants |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Primary |
Short-term difference in perfusion defect percent assessed by perfusion SPECT-CT - healthy |
The short-term difference in lung perfusion between healthyCOVID-19+ and healthyCOVID-19- participants |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Primary |
Short-term difference in lung ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - healthy |
The short-term difference in lung ventilation/perfusion mismatch between healthyCOVID-19+ and healthyCOVID-19- participants |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Primary |
Long-term difference in ventilation defect percent assessed by ventilation SPECT-CT - healthy |
The long-term difference in lung ventilation between healthyCOVID-19+ and healthyCOVID-19- participants |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Long-term difference in perfusion defect percent assessed by perfusion SPECT-CT - healthy |
The long-term difference in lung perfusion between healthyCOVID-19+ and healthyCOVID-19- participants |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Long-term difference in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - healthy |
The long-term difference in lung ventilation/perfusion mismatch between healthyCOVID-19+ and healthyCOVID-19- participants |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Short-term difference in ventilation defect percent assessed by ventilation SPECT-CT - asthmatic |
The short-term difference in lung ventilation between asthmaticCOVID-19+ and asthmaticCOVID-19- participants |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Primary |
Short-term difference in perfusion defect percent assessed by perfusion SPECT-CT - asthmatic |
The short-term difference in lung perfusion between asthmaticCOVID-19+ and asthmaticCOVID-19- participants |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Primary |
Short-term difference in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - asthmatic |
The short-term difference in lung ventilation/perfusion mismatch between asthmaticCOVID-19+ and asthmaticCOVID-19- participants |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Primary |
Long-term difference in ventilation defect percent assessed by ventilation SPECT-CT - asthmatic |
The long-term difference in lung ventilation between asthmaticCOVID-19+ and asthmaticCOVID-19- participants |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Long-term difference in perfusion defect percent assessed by perfusion SPECT-CT - asthmatic |
The long-term difference in lung perfusion between asthmaticCOVID-19+ and asthmaticCOVID-19- participants |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Long-term difference in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - asthmatic |
The long-term difference in lung ventilation/perfusion mismatch between asthmaticCOVID-19+ and asthmaticCOVID-19- participants |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Longitudinal change in ventilation defect percent assessed by ventilation SPECT-CT - healthy |
Difference in the 6-month change in lung ventilation between healthyCOVID-19+ and healthyCOVID-19- participants |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Longitudinal change in perfusion defect percent assessed by perfusion SPECT-CT - healthy |
Difference in the 6-month change in lung perfusion between healthyCOVID-19+ and healthyCOVID-19- participants |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Longitudinal change in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - healthy |
Difference in the 6-month change in lung ventilation/perfusion mismatch between healthyCOVID-19+ and healthyCOVID-19- participants |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Longitudinal change in ventilation defect percent assessed by ventilation SPECT-CT - asthmatic |
Difference in the 6-month change in lung ventilation between asthmaticCOVID-19+ and asthmaticCOVID-19- participants. |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Longitudinal change in perfusion defect percent assessed by perfusion SPECT-CT - asthmatic |
Difference in the 6-month change in lung perfusion between asthmaticCOVID-19+ and asthmaticCOVID-19- participants. |
6-months post COVID-19 recovery (Visit 2) |
|
Primary |
Longitudinal change in ventilation/perfusion mismatch assessed by ventilation/perfusion SPECT-CT - asthmatic |
Difference in the 6-month change in lung ventilation/perfusion mismatch between asthmaticCOVID-19+ and asthmaticCOVID-19- participants. |
6-months post COVID-19 recovery (Visit 2) |
|
Secondary |
Correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score =4-weeks post COVID-19 recovery |
In COVID-19+ participants, the correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score =4-weeks post COVID-19 recovery (Visit 1). |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Secondary |
Correlation of lung ventilation with six-minute walk distance (6MWD) =4-weeks post COVID-19 recovery |
In COVID-19+ participants, the correlation of lung ventilation with six-minute walk distance (6MWD) =4-weeks post COVID-19 recovery (Visit 1). |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Secondary |
Correlation of lung ventilation with the forced expiratory volume in one second (FEV1) =4-weeks post COVID-19 recovery |
In COVID-19+ participants, the correlation of lung ventilation with the forced expiratory volume in one second (FEV1) =4-weeks post COVID-19 recovery (Visit 1). |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Secondary |
Correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) =4-weeks post COVID-19 recovery |
In COVID-19+ participants, the correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) =4-weeks post COVID-19 recovery (Visit 1). |
=4-weeks post COVID-19 recovery (Visit 1) |
|
Secondary |
Correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score 6-months post COVID-19 recovery |
In COVID-19+ participants, the correlation of lung ventilation with the St. George's Respiratory Questionnaire (SGRQ) score 6-months post COVID-19 recovery (Visit 2). |
6-months post COVID-19 recovery (Visit 2) |
|
Secondary |
Correlation of lung ventilation with six-minute walk distance (6MWD) 6-months post COVID-19 recovery |
In COVID-19+ participants, the correlation of lung ventilation with six-minute walk distance (6MWD) 6-months post COVID-19 recovery (Visit 2). |
6-months post COVID-19 recovery (Visit 2) |
|
Secondary |
Correlation of lung ventilation with the forced expiratory volume in one second (FEV1) 6-months post COVID-19 recovery |
In COVID-19+ participants, the correlation of lung ventilation with the forced expiratory volume in one second (FEV1) 6-months post COVID-19 recovery (Visit 2). |
6-months post COVID-19 recovery (Visit 2) |
|
Secondary |
Correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) 6-months post COVID-19 recovery |
In COVID-19+ participants, the correlation of lung ventilation with the diffusing capacity of the lung for carbon monoxide (DLCO) 6-months post COVID-19 recovery (Visit 2). |
6-months post COVID-19 recovery (Visit 2) |
|