Memory Perception Assessment in Central/Non-central Nervous System Cancers

Healthy Clinical Trial

— PROMESSE  

Official title:

Prospective and Retrospective Memory Perception Assessment in Central/Non-central Nervous System Cancers

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT03975959
• Other study ID #: PROICM 2018-07 BPR
• Status: Recruiting
• Phase: N/A
• Start date: May 10, 2019
• Est. completion date: October 30, 2024

Study information

• Verified date: June 2024
• Source: Institut du Cancer de Montpellier - Val d'Aurelle
• Contact: Moussion Aurore
• Phone: +33467612446
• Email: aurore.moussion[@]icm.unicancer.fr
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Prospective memory (PM) is the ability to implement intended actions in the future. It allows maintaining and retrieving future plans, goals, and activities (i.e., remember to remember). PM is associated with most everyday memory problems . PM is crucial to correctly respond to all the social, occupational and working demands of everyday life, to perform many deferred health-related actions and is involved in therapeutic adherence . Indeed, PM errors are an important part of the aging memory complaints. The prevalence of self-reported PM failures is also significant among young adults, compared with self-reported retrospective memory (RM) failures .Yet, PM errors are major sources of frustration and embarrassment . In oncology, recently investigated the self-reported memory complaints in a 80 case-healthy-control study breast patients . Subjective memory complaints were assessed using the Prospective and Retrospective Memory Questionnaire . Results from the Paquet et al. study show that all participants (i.e., both patients and matched-controls) reported more PM than RM failures in daily-life (p<.001). Breast cancer patients reported more RM and PM failures than controls. However, this group effect was no longer statistically significant when controlling for depression and fatigue. These findings are consistent with the view that memory complaints are closely associated with depression and cancer-related fatigue, and more generally with psychopathological variables .As underlined by Paquet et al. subjective memory complaints should be investigated because they refer to some aspects of the cancer experience that could potentially be linked to quality of life. Thus, it is important to explore psychopathological basis such as depression, anxiety and fatigue while investigating self-reported memory failures in cancer patients. Despites the importance of PM, there have been, to our knowledge, only few studies evaluating PM complaints or PM functioning in patients diagnosed with an intracerebral tumor (such as Diffuse Low-Grade Glioma- DLGG- or glioblastome- GB) or extra-cerebral tumor (such as breast cancer - BC). Therefore, the investigators thought it would be useful, as a first step, to conduct a study to explore and to manage the PM and RM subjective complaints in cancer patients compared to another chronic disease, such as HIV. In fine, these data will help to identify a new target for psychological management focused on either psychopathological or neuropsychological rehabilitation

Description:

Primary objective : This study will aim at determining the nature of subjective memory complaints (i.e., prospective or retrospective memory) in cancer patients with intra- cerebral tumors (Glioblastomas and Diffuse Low Grade Gliomas) and extra cerebral tumors (Breast cancer) compared with controls. The protocol administration will take about 20 minutes. It will be conducted by an experienced clinical neuropsychologist or clinical oncologist in each center during standard care. According to the results on the questionnaires and test, patients will be addressed and managed by a neuropsychologist, a clinical psychologist, psychiatrist or a speech therapist.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 420
• Est. completion date: October 30, 2024
• Est. primary completion date: June 30, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

All the participants must fulfill all the following criteria to be eligible for study

entry:

• Be aged of 18 to 80 years old
• Have a ECOG Performance Status = 2 or a Karnofsky index = 50 %
• Have a satisfactory level of French
• Have signed the informed consent

Also, for the DLGG group, the patients must:

• Have a histologically-proven diagnosis of DLGG (i.e., WHO grade II glioma)
• Receive or have received a first oncological treatment after surgery (chemotherapy, radiation therapy…)

Also, for the GB group, the patients must:

• Have a histologically-proven diagnosis of GB (i.e., WHO grade IV glioma).

Also, for the breast cancer group, the patients must:

• Have a histologically-proven diagnosis of breast cancer diagnosed < 2 years. Exclusion Criteria: Participants presenting with any of the following exclusion criteria will not be included

in the study:

• Patients with brain metastases
• Patients under tutorship or curatorship or protective measures
• Patients suffering from sensorial or motor deficits avoiding the tests administration
• Patients with a reported history of psychiatric disease (e.g., mental retardation, psychotic disorders, learning disabilities, attention-deficit/hyperactivity disorder, and bipolar disorder)
• Have reported a substance dependence within the past six months (e.g., cocaine or methamphetamine dependence)
• Pregnant women
• Legal incapacity or physical, psychological social or geographical status interfering with the patient's ability to sign the informed consent or to terminate the study

Also, for the DLGG group, the patients must not:

• Have an anaplastic glioma (i.e., WHO grade III glioma)
• Have a DLGG with radiological or histological signs of anaplastic transformation
• Have a history of HIV
• Have a history of other cancer

Also, for the GB group, the patients must not:

• Patients treated with =2 lines of systemic cancer treatment (e.g., patient after the first GB recurrence)
• Have a history of HIV
• Have a history of other cancer

Also, for the breast cancer group, the patients must not:

• Have a metastatic disease
• Have a neoadjuvant therapy
• Have a documented neurological, or substance use disorders.
• Have a history of HIV
• Have a history of other cancer
• Have reported a history of neurological diagnoses (e.g., seizure disorders, closed head injuries with loss of consciousness greater than 15 min).

Also for the control group, the participants must not:

• Have a documented neurological, or substance use disorders
• Have a history of cancer
• Have a history of HIV

Related Conditions & MeSH terms

• Breast Cancer
• Glioblastoma
• Glioma
• Healthy
• Nervous System Neoplasms

Intervention

Other:
• QMRP questionnaire
a single consultation for test and questionnaires for a duration of 20 minutes

Locations

Country	Name	City	State
France	CHU D'amiens	Amiens	Nord
France	Hôpital d'Instruction des Armées	Clamart
France	Icm Val D'Aurelle	Montpellier	Herault
France	Hopital saint Louis	Paris
France	CHU Lyon	Saint-Genis-Laval
France	UFR de Psychologie Université de Lille	Villeneuve-d'Ascq	Nord

Sponsors (1)

Lead Sponsor	Collaborator
Institut du Cancer de Montpellier - Val d'Aurelle

Country where clinical trial is conducted

France, 

References & Publications (34)

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* Note: There are 34 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the nature of subjective memory complaints	scores from 8 to 40 of QMRP questionnaire	12 months
Secondary	the significant psychopathological correlates of the subjective PM and RM complaints	Scores on the Hospital Anxiety Depression Scale from 0-21	12 months
Secondary	the significant correlates between the subjective PM and RM complaints and the subjective fatigues	Scores on the Multidimensional Fatigue Inventory-20	12 months
Secondary	the significant correlates between the subjective PM and RM complaints	Scores (from 0 to 30) on the Montreal Cognitive Assessment	12 months
Secondary	the effect of disease on the subjective PM and RM complaints	comparison of clinical event between each group	12 months
Secondary	the effect of cancer on the subjective PM and RM complaints	questionnaire : frontal assessment battery compared between each groups	12 months
Secondary	the significant correlates between the subjective PM and RM complaints	questionnaire : frontal assessment battery score 0-18	12 months