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Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane — PHOENIX1  

Healthy Clinical Trial

Official title:
Prevention of Heart Failure Induced by Doxorubicin With Early Administration of Dexrazoxane in Patients With Breast Cancer

Clinical Trial Summary

The purpose of this research study is to determine whether early administration of Dexrazoxane prevents Doxorubicin induced cardiotoxicity.

Clinical Trial Description

This is a study on volunteers to determine effective dose of dexrazoxane in degrading Topoisomerase 2 b in human blood samples. Each participant will receive one dose of dexrazoxane. Blood samples will be collected to determine the time course and degradation of Topoisomerase 2b and Topoisomerase 2a ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03930680
Study type Interventional
Source University of Arkansas
Contact Hui-Ming Chang, MD,MPH
Phone 501-686-7575
Email hchang@uams.edu
Status Recruiting
Phase Phase 1
Start date September 14, 2021
Completion date October 31, 2025
View Details
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