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Molecular and Hormonal Responses to Diet-Induced Insulin Resistance

Healthy Clinical Trial

Official title:
Molecular and Hormonal Responses to Diet-Induced Insulin Resistance

Clinical Trial Summary

This study determined the effect of 7 days of high-fat overfeeding on whole-body glycaemic control, glucose kinetics, skeletal muscle insulin signalling, and markers of skeletal muscle microvascular function in 15 healthy young individuals.

Clinical Trial Description

Fifteen healthy, young individuals underwent metabolic testing before and after 7 days of high-fat overfeeding. We determined whole-body glycaemic control, glucose kinetics, skeletal muscle insulin signalling, and markers of skeletal muscle microvascular function. Stable isotope tracers were used to assess the rate of appearance of glucose from the gut, liver glucose output and whole-body glucose disposal. Insulin signalling was determined by Western blotting of skeletal muscle tissue. Microvascular function was assessed through the use of quantitative immunofluorescence microscopy. These measurements were performed both postabsorptively and following the ingestion of 50 grams of glucose + 15 grams of protein. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03879187
Study type Interventional
Source Loughborough University
Contact
Status Completed
Phase N/A
Start date March 2, 2015
Completion date May 22, 2018
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