Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis

Healthy Clinical Trial

— 2d-BR  

Official title:

The Impact of Two Days of Bed Rest Versus Two Days of Habitual Activity on Insulin Sensitivity and Cumulative Muscle Protein Synthesis in Healthy Young Males

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT03877822
• Other study ID #: 190206/B/05
• Status: Withdrawn
• Phase: N/A
• Start date: September 1, 2021
• Est. completion date: September 1, 2021

Study information

• Verified date: November 2021
• Source: University of Exeter
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males

Description:

To study the mechanisms underlying inactivity-induced muscle atrophy, the impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: September 1, 2021
• Est. primary completion date: September 1, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Male

• Aged 18-40

Exclusion Criteria:

• Smoker

• Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes)

• Any diagnosed cardiovascular disease (e.g. deep vein thrombosis or hypertension)

• Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism).

• A personal or family history of thrombosis, epilepsy, seizures or schizophrenia.

• Any known disorders in muscle metabolism

• Regular use of nutritional supplements (i.e. ingestion more than twice per week during the last month)

• Metallic implants (including heart pacemaker, cochlear implants, medication pumps, surgical clips, plates or screws).

• Allergy to lidocaine

• Recent (within the last 6 months) or current musculoskeletal injury (e.g. leg fracture)

Related Conditions & MeSH terms

• Healthy
• Insulin Resistance

Intervention

Behavioral:
• Habitual activity
Two days of habitual physical activity, under normal free-living conditions
• Bed rest
Two days of bed rest, to induce whole-body physical inactivity

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Exeter

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in whole-body insulin sensitivity	Change in whole-body insulin sensitivity via meal tolerance test	During 2 days of habitual physical activity and 2 days of bed rest. Blood glucose and insulin are monitored for 2 hours following ingestion of a standardized meal
Secondary	Change in cumulative muscle protein synthesis	Cumulative muscle protein synthesis via deuterium oxide ingestion. The incorporation of deuterated alanine in muscle is expressed relative to body water enrichments, to obtain muscle protein synthesis in %/day	During 2 days of habitual physical activity and 2 days of bed rest
Secondary	Change in continuous glucose	Change in continuous glucose via continuous glucose monitoring.	Continuous glucose, during the 2 days of habitual activity and 2 days of bed rest
Secondary	Change in muscle volume	Change in muscle volume via MRI	Immediately before and immediately after the 2-day bed rest period