Cerebrovascular Response to Acute Exercise

Healthy Clinical Trial

Official title:

The Role of Shear Stress in the Cerebrovascular Response to Acute Exercise

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03722953
• Other study ID #: 2018-0783
• Secondary ID: A176000EDUC/KINE
• Status: Completed
• Phase: N/A
• Start date: December 1, 2018
• Est. completion date: March 9, 2020

Study information

• Verified date: June 2022
• Source: University of Wisconsin, Madison
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Cerebrovascular function and peripheral vascular function will be measured in healthy young adults, before and after acute bouts of aerobic exercise at various intensities.

Description:

Acute bouts of aerobic exercise have been shown to enhance vascular reactivity of the peripheral circulation; however, the effects of a single exercise session on the cerebral circulation are unknown. This study will measure cerebrovascular function and peripheral vascular function before and after aerobic exercise at high and low intensities.

The research aims are:

1. To determine if a single bout of aerobic exercise acutely enhances cerebrovascular function

2. To determine the effect of aerobic exercise intensity and dose on cerebrovascular function in healthy adults.

3. To determine if the acute exercise-induced changes in cerebrovascular function are associated with acute exercise-induced changes in peripheral vascular function in healthy adults.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: March 9, 2020
• Est. primary completion date: March 9, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 40 Years

Eligibility

Inclusion Criteria:

• Between 20-40 years old

• BMI < 30 kg/m2

• Recreationally active

• Experience running on a treadmill

Exclusion Criteria:

• Current smoker

• History or evidence of: hepatic disease, renal disease, hematological disease, cardiovascular disease, stroke/neurovascular disease, diabetes

• Taking blood pressure medication

• History of depression or other mood related disorders

• Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)

Related Conditions & MeSH terms

• Healthy
• Physical Activity

Intervention

Other:
• Control
Ultrasound Blood Pressure Heart Rate Oxygen Saturation
• Aerobic Exercise
Ultrasound Blood Pressure Heart Rate Oxygen Saturation

Locations

Country	Name	City	State
United States	Gymnasium-Natatorium	Madison	Wisconsin

Sponsors (1)

Lead Sponsor	Collaborator
University of Wisconsin, Madison

Country where clinical trial is conducted

United States, 

References & Publications (25)

Barnes JN, Harvey RE, Miller KB, Jayachandran M, Malterer KR, Lahr BD, Bailey KR, Joyner MJ, Miller VM. Cerebrovascular Reactivity and Vascular Activation in Postmenopausal Women With Histories of Preeclampsia. Hypertension. 2018 Jan;71(1):110-117. doi: 10.1161/HYPERTENSIONAHA.117.10248. Epub 2017 Nov 20. — View Citation

Barnes JN, Nualnim N, Dhindsa M, Renzi CP, Tanaka H. Macro- and microvascular function in habitually exercising systemic lupus erythematosus patients. Scand J Rheumatol. 2014;43(3):209-16. doi: 10.3109/03009742.2013.846408. Epub 2014 Jan 7. — View Citation

Barnes JN, Schmidt JE, Nicholson WT, Joyner MJ. Cyclooxygenase inhibition abolishes age-related differences in cerebral vasodilator responses to hypercapnia. J Appl Physiol (1985). 2012 Jun;112(11):1884-90. doi: 10.1152/japplphysiol.01270.2011. Epub 2012 Mar 22. — View Citation

Barnes JN, Taylor JL, Kluck BN, Johnson CP, Joyner MJ. Cerebrovascular reactivity is associated with maximal aerobic capacity in healthy older adults. J Appl Physiol (1985). 2013 May 15;114(10):1383-7. doi: 10.1152/japplphysiol.01258.2012. Epub 2013 Mar 7. — View Citation

Buratti L, Viticchi G, Falsetti L, Balucani C, Altamura C, Petrelli C, Provinciali L, Vernieri F, Silvestrini M. Thresholds of impaired cerebral hemodynamics that predict short-term cognitive decline in asymptomatic carotid stenosis. J Cereb Blood Flow Metab. 2016 Oct;36(10):1804-1812. Epub 2015 Oct 27. — View Citation

Dawson EA, Green DJ, Cable NT, Thijssen DH. Effects of acute exercise on flow-mediated dilatation in healthy humans. J Appl Physiol (1985). 2013 Dec;115(11):1589-98. doi: 10.1152/japplphysiol.00450.2013. Epub 2013 Sep 12. — View Citation

Dhindsa M, Sommerlad SM, DeVan AE, Barnes JN, Sugawara J, Ley O, Tanaka H. Interrelationships among noninvasive measures of postischemic macro- and microvascular reactivity. J Appl Physiol (1985). 2008 Aug;105(2):427-32. doi: 10.1152/japplphysiol.90431.2008. Epub 2008 May 15. — View Citation

Endres M, Gertz K, Lindauer U, Katchanov J, Schultze J, Schröck H, Nickenig G, Kuschinsky W, Dirnagl U, Laufs U. Mechanisms of stroke protection by physical activity. Ann Neurol. 2003 Nov;54(5):582-90. — View Citation

Iadecola C, Zhang F. Nitric oxide-dependent and -independent components of cerebrovasodilation elicited by hypercapnia. Am J Physiol. 1994 Feb;266(2 Pt 2):R546-52. — View Citation

Ide K, Secher NH. Cerebral blood flow and metabolism during exercise. Prog Neurobiol. 2000 Jul;61(4):397-414. Review. — View Citation

LASSEN NA. Cerebral blood flow and oxygen consumption in man. Physiol Rev. 1959 Apr;39(2):183-238. — View Citation

Meza S, Mendez M, Ostrowski M, Younes M. Susceptibility to periodic breathing with assisted ventilation during sleep in normal subjects. J Appl Physiol (1985). 1998 Nov;85(5):1929-40. — View Citation

Miller KB, Howery AJ, Harvey RE, Eldridge MW, Barnes JN. Cerebrovascular Reactivity and Central Arterial Stiffness in Habitually Exercising Healthy Adults. Front Physiol. 2018 Aug 17;9:1096. doi: 10.3389/fphys.2018.01096. eCollection 2018. — View Citation

Mitchell GF. Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage. J Appl Physiol (1985). 2008 Nov;105(5):1652-60. doi: 10.1152/japplphysiol.90549.2008. Epub 2008 Sep 4. Review. — View Citation

Molina C, Sabín JA, Montaner J, Rovira A, Abilleira S, Codina A. Impaired cerebrovascular reactivity as a risk marker for first-ever lacunar infarction: A case-control study. Stroke. 1999 Nov;30(11):2296-301. — View Citation

Moraine JJ, Lamotte M, Berré J, Niset G, Leduc A, Naeije R. Relationship of middle cerebral artery blood flow velocity to intensity during dynamic exercise in normal subjects. Eur J Appl Physiol Occup Physiol. 1993;67(1):35-8. — View Citation

Morrell MJ, Harty HR, Adams L, Guz A. Changes in total pulmonary resistance and PCO2 between wakefulness and sleep in normal human subjects. J Appl Physiol (1985). 1995 Apr;78(4):1339-49. — View Citation

Ogoh S, Sørensen H, Hirasawa A, Sasaki H, Washio T, Hashimoto T, Bailey DM, Secher NH. Dynamic cerebral autoregulation is unrelated to decrease in external carotid artery blood flow during acute hypotension in healthy young men. Exp Physiol. 2016 Aug 1;101(8):1040-9. doi: 10.1113/EP085772. Epub 2016 Jun 21. — View Citation

Ranjan V, Xiao Z, Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol. 1995 Aug;269(2 Pt 2):H550-5. — View Citation

Richiardi J, Monsch AU, Haas T, Barkhof F, Van de Ville D, Radü EW, Kressig RW, Haller S. Altered cerebrovascular reactivity velocity in mild cognitive impairment and Alzheimer's disease. Neurobiol Aging. 2015 Jan;36(1):33-41. doi: 10.1016/j.neurobiolaging.2014.07.020. Epub 2014 Jul 24. — View Citation

Sam K, Crawley AP, Conklin J, Poublanc J, Sobczyk O, Mandell DM, Venkatraghavan L, Duffin J, Fisher JA, Black SE, Mikulis DJ. Development of White Matter Hyperintensity Is Preceded by Reduced Cerebrovascular Reactivity. Ann Neurol. 2016 Aug;80(2):277-85. doi: 10.1002/ana.24712. — View Citation

Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain. 2007 Sep;130(Pt 9):2310-9. Epub 2007 Jul 16. — View Citation

Tanaka H, Shimizu S, Ohmori F, Muraoka Y, Kumagai M, Yoshizawa M, Kagaya A. Increases in blood flow and shear stress to nonworking limbs during incremental exercise. Med Sci Sports Exerc. 2006 Jan;38(1):81-5. — View Citation

Tarumi T, Zhang R. Cerebral hemodynamics of the aging brain: risk of Alzheimer disease and benefit of aerobic exercise. Front Physiol. 2014 Jan 21;5:6. doi: 10.3389/fphys.2014.00006. eCollection 2014. Review. — View Citation

Tinken TM, Thijssen DH, Hopkins N, Black MA, Dawson EA, Minson CT, Newcomer SC, Laughlin MH, Cable NT, Green DJ. Impact of shear rate modulation on vascular function in humans. Hypertension. 2009 Aug;54(2):278-85. doi: 10.1161/HYPERTENSIONAHA.109.134361. Epub 2009 Jun 22. — View Citation

* Note: There are 25 references in all — Click here to view all references

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Cerebrovascular function	Utilize ultrasound to measure a change in blood flow velocity in response to a breathing test	Change in cerebrovascular function: measurements occur at baseline and 90 minutes post aerobic exercise to quantify magnitude of change.
Primary	Peripheral vascular function	Utilize ultrasound to measure a change in brachial artery diameter in response to reactive hyperemia	Change in peripheral vascular function: measurements occur at baseline and 60 minutes post aerobic exercise to quantify magnitude of change.