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Pain Inhibition and Facilitation in Recurrent Low Back Pain

Healthy Clinical Trial

Official title:
Pro-Nociceptive and Anti-Nociceptive Mechanisms Across an Episode of Recurrent Low Back Pain

Clinical Trial Summary

This study evaluates psychophysical measures of pain inhibition and facilitation, along with cortical responses to different sensory stimuli, in patients with recurrent low back pain and matched healthy individuals.

Clinical Trial Description

Pain inhibitory and facilitatory mechanisms have been suggested to play a role in the development of persistent low back pain; however, there is still debate on when changes in these mechanisms occur. Similarly, evoked cortical responses can reflect neuroplastic changes in pain processing regions, which are also thought to play a role in the transition to persistent pain, but there is also debate on when these neuroplastic changes develop relative to low back pain. Therefore, this study will use patients with an intermediary clinical pain state, recurrent low back pain, and matched healthy control participants, to investigate within and between subject differences in pain inhibitory, facilitatory and neuroplastic mechanisms. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03463759
Study type Observational
Source Aalborg University
Contact
Status Completed
Phase
Start date April 10, 2018
Completion date December 14, 2019
View Details
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