Healthy Clinical Trial
Official title:
Cognitive, Emotional, and Neural Responses to Acute Inflammation
This study is a pilot study to examine the effects of acute inflammation on cognition and emotion in healthy participants using a between-subjects, randomized, double-blind design.
The inflammatory response of the immune system is responsive to stress and it impacts brain
function. Animal studies have shown that inflammation appears to alter threat- and
reward-related brain activity. Accumulating evidence points to inflammatory proteins,
specifically cytokines, as key players in this relationship. Although cytokines are typically
too large to pass through the blood brain barrier (BBB), they can influence brain function
and structure by transmitting signals from peripheral systems to the brain.
The administration of endotoxin within the polysaccharide form of Salmonella typhi
vaccination provides an ideal model for studying the causal effects of short-term
inflammation on thinking patterns (i.e., cognition) and emotions in the brain. Endotoxin is a
component of the cell walls of Gram-negative bacteria, which promotes the production of
pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor alpha
(TNF-α) via toll-like receptor-4 (TLR-4) activation and nuclear factor- κB (NF-κB) signaling.
To examine the effects of acute inflammation on brain functioning, 24 healthy participants
will be recruited. The investigators will will randomize participants to placebo or
inflammatory challenge using polysaccharide typhoid vaccine (i.e., endotoxin) and will use
validated behavioral tasks and questionnaires to assess threat and reward sensitivity. They
will assess chronic resting levels of inflammation as well as the inflammatory response to
Salmonella typhi vaccination.
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