Healthy Clinical Trial
Official title:
Validation of the Quark RMR Calorimeter (Cosmed) Versus Deltatrac II (GE Health Care Clinical Systems) for Measuring Energy Expenditure at Rest and in Dynamic Phase After a Meal in Adult Healthy and Obese Volunteers
Measurement of energy expenditure at rest (12 hours fasting) and in dynamic phase after a meal (600kcal) to compare the results of the two calorimeters in standardized conditions for the validation of quark RMR versus Deltatrac II
Clinically, energy expenditure is usually estimated using predictive equations, such as the
Harris-Benedict equation, which consider the patient's weight, height, age and sex to
determine energy needs. However these have been shown to be unsystematically incorrect and
may vary by 70-140% when compared with indirect and direct calorimetry measurements.
That is why the most popular method of measurement of energy expenditure in research is via
indirect calorimetry using a metabolic cart. Indirect calorimetry is the measurement of the
volume of oxygen consumption and carbon dioxide production.
Actually, there are few numbers of indirect calorimeters available commercialy. The
Deltatrac II metabolic cart was the gold standard. It has been extensively used in clinical
research both for resting metabolic rate and substrate oxidation measurement during
postprandial or an insulin clamp. The Quark RMR is also a metabolic cart too which was
launched on the market to compete with the others calorimeters measuring resting metabolic
rate.
As the Quark RMR and Deltatrac II use the same measure device (paramagnetic analyser for
oxygen detection, infrared absorption for carbon dioxide detection) with the same
sensitivity and time response according to constructor's data, we want to compare these two
calorimeters for the measurement of energy expenditure and substrate oxidation at rest and
during a meal in standardized conditions.
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Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Health Services Research
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