Healthy Clinical Trial
Official title:
Pulmonary Fibrosis Associated With Rheumatoid Arthritis: Identification of Genetic Polymorphisms
Verified date | December 28, 2007 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Pulmonary fibrosis (PF) is a condition in which the lungs of a patient become scarred and
fibrous. It has been known to occur in as many as 40% of patients diagnosed with rheumatoid
arthritis (RA). The cause of the pulmonary fibrosis in patients with RA is unknown.
Data gathered from previous research studies suggest that genetics may play a role in the
development of PF in patients with rheumatoid arthritis. However, the actual genetic factors
involved in the disease process have not been identified.
The goal of this study is to identify the genetic markers in patients with pulmonary fibrosis
and rheumatoid arthritis.
Status | Completed |
Enrollment | 400 |
Est. completion date | December 28, 2007 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 21 Years and older |
Eligibility |
- INCLUSION CRITERIA: Individuals 21 years of age or older with any of the following: RA (based on 1987 American College of Rheumatology Revised Criteria for the Classification of RA) with PF (biopsy-proven), or RA-only, or Biopsy-proven idiopathic PF-only, or Healthy research volunteers. EXCLUSION CRITERIA: Individuals with any of the following: Inhalational exposure to fibrogenic fibers or dusts (e.g., asbestos, silica, coal, beryllium). Chronic pulmonary disorders other than pulmonary fibrosis. Other collagen vascular disorders (e.g., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease). Non-rheumatoid arthritis. Viral infections associated with PF (e.g., hepatitis B, hepatitis C, human immunodeficiency virus). Pregnancy. |
Country | Name | City | State |
---|---|---|---|
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Heart, Lung, and Blood Institute (NHLBI) |
United States,
Hakala M. Poor prognosis in patients with rheumatoid arthritis hospitalized for interstitial lung fibrosis. Chest. 1988 Jan;93(1):114-8. — View Citation
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