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Applied Cognition Benchmarking Study — BRAIN3  

Healthy Clinical Trial

Official title:
Measuring and Monitoring Brain Health in Older Adults: The Applied Cognition Glymphatic Function Study at The Villages

Clinical Trial Summary

This is a cross-over randomized study to validate the Sponsor investigational medical device against measurements of glymphatic function from MRI-based neuroimaging, EEG, blood biomarkers and cognitive tests in healthy older volunteers.

Clinical Trial Description

The study population will consist of healthy individuals, ages 55 to 65, that are cognitively normal and do not have a medical history of neurological or sleep disorder, cardiovascular disease, hypertension, or diabetes. The objectives of this study are to define whether sleep- and wake-associated device measurements (i) faithfully reflect glymphatic function measured by gold-standard contrast enhanced MRI and non-invasive MRI-based measures of glymphatic function; (ii) replicate pre-clinical findings between sleep EEG power bands and glymphatic flow; (iii) predict plasma levels of Alzheimer's disease (AD)-related biomarkers; and (iv) predict morning cognitive performance. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06222385
Study type Interventional
Source Applied Cognition
Contact
Status Completed
Phase N/A
Start date November 7, 2022
Completion date June 8, 2023
View Details
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