| Eligibility |
Inclusion Criteria:
- Age between 18 and 40 years (limits included),
- BMI between 18.5 and 30 kg/m² (limits included),
- Able and willing to drink 250mL of milk in 5 minutes,
- Good general and mental health with in the opinion of the investigator: no clinically
significant and relevant abnormalities of medical history or clinical examination,
- Able and willing to participate to the study by complying with the protocol procedures
as evidenced by his dated and signed informed consent form,
- Affiliated with a social security scheme,
- For milk intolerant subjects: self-reporting symptoms after drinking milk and drinking
less than 150mL of cow's milk (lactose-free milk not included) per week (assessed by
the gastrointestinal symptoms questionnaire filled out at V0).
- For milk tolerant subjects: drinking at least 700mL of cow's milk (lactose-free milk
not included) per week (assessed by the gastrointestinal symptoms questionnaire filled
out at V0).
Exclusion Criteria:
- Suffering from a metabolic disorder such as diabetes, uncontrolled thyroidal trouble,
uncontrolled arterial hypertension or other metabolic disorder,
- Suffering from a severe chronic disease (e.g. cancer, HIV, renal failure, hepatic or
biliary disorders ongoing, chronic inflammatory digestive disease, arthritis, etc.) or
disorders found to be inconsistent with the conduct of the study by the investigator,
- Suffering from any obstructive or restrictive respiratory syndrome (COPD, asthma,
etc.) that may impact breath test measurements,
- Suffering from a gastro-intestinal pathology (inflammatory bowel disease, Crohn
disease, ulcerative colitis, irritable bowel syndrome, celiac disease, gluten
hypersensitivity, small intestinal bacterial overgrowth, diverticulitis, polyps,
constipation, esophageal motility abnormality, history of gastric bezoar...), or other
gastro-intestinal disorders found to be inconsistent with the conduct of the study by
the investigator,
- Suffering from any disorder found to be inconsistent with the conduct of the study by
the investigator,
- With a history of gastro-intestinal surgery (only appendectomy is accepted),
- With swallowing problems,
- With a known or suspected allergy to cows' milk protein,
- With a lactose intolerance diagnosed by a positive Lactose Breath Test,
- Pregnant or lactating women or intending to become pregnant during the study,
- Under treatment or dietary supplement which could significantly affect the gut
motility and/or interfere with gastric emptying time and/or affect the gut pH during
the study according to the investigator or stopped less than 15 days before the V0
visit (examples: NSAIDs, proton pump inhibitors, prokinetics, treatments against
diarrhea or constipation, etc.),
- Regular intake of dietary supplements containing prebiotics, probiotics or symbiotics,
or stopped less than 3 months before the V0 visit,
- With significant change in food habits or in physical activity in the 3 months before
the V0 visit or not agreeing to keep them unchanged throughout the study,
- Weight loss or gain > 5% of body weight in the 6 months before the study,
- With a current diet or stopped less than 3 months before the study,
- With a current eating disorder (anorexia nervosa, bulimia, etc.) according to the
investigator,
- Consuming more than 2 standard drinks of alcoholic beverage daily regularly and not
agreeing to keep alcohol consumption habits unchanged throughout the study,
- Smoker (electronic cigarette not allowed),
- Consuming illicit drugs,
- Having an implanted or portable electro-mechanical medical device (such as pacemakers,
defibrillators, infusion pumps…etc),
- Taking part in another clinical trial or being in the exclusion period of a previous
clinical trial,
- Under legal protection (guardianship, wardship) or deprived from his rights following
administrative or judicial decision,
- Presenting a psychological or linguistic incapability to sign the informed consent,
- Impossible to contact in case of emergency.
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