Healthy Clinical Trial
Official title:
Differential Analysis of Uric Acid Metabolism, Endothelial Function, Oxidative Stress and Cardiovascular Parameters in Vegans and Omnivores.
50 vegans and 50 omnivores will be recruited at the Erasme Hospital, Brussels.
Hypothesis
- Relative induced-hyperuricemia by the vegan diet is not associated with impaired
endothelial function if vitamin B12 and folic acid levels are normal.
- Quantification of xanthine oxidoreductase (XOR) isoforms varies according to the diet.
Omnivores present more xanthine oxidase (XO) than vegans in which the xanthine
dehydrogenase (XD) isoform is more prevalent.
- The vegan group has more favorable oxidant, metabolic and inflammatory profiles than the
omnivore group.
Non-meat eaters rise widely worldwide. This choice answers ideological, ecological or health
concerns. Several vegetarian diets exist and the vegan diet is the most restricted one as it
excludes all animal products, eggs and dairy.
Beside benefits on health and particularly on the cardiovascular system (blood pressure,
weight, lipid profile), some authors described less favorable lipid and oxidative profiles
and others described an impairment in endothelial function markers in 'vegans'. These effects
were attributed to low vitamin B12 and folate levels and high homocystein levels. However,
vitamin B12 supplementation improved these parameters. Epidemiological studies also showed
that 'vegans' disclose higher uric acid levels than other vegetarians or omnivores. Uric acid
acts as an antioxidant in the plasma but can be deleterious for vascular cells leading to
endothelial dysfunction. The main enzyme involved in uric acid metabolism is xanthine
oxidoreductase which exists under two interconvertible isoforms. Xanthine dehydrogenase is
the main form and uses nicotinamide adenine dinucleotide (NAD+) as electron acceptor and does
not produce reactive oxygen species (ROS). In contrast, the other isoform xanthine oxidase
uses oxygen as an electron acceptor and produces reactive oxygen species (ROS). The
investigators wish to test the hypothesis that it is not uric acid per se, but which isoform
of xanthine oxidoreductase which alters endothelial function. This is why the investigators
wish to determine if regular 'vegans' (with normal vitamin B12 and folate levels) disclose
increased uric acid levels in the presence of a reduced inflammation, oxidative stress and
improved endothelial function, as compared to matched 'omnivores'.
50 vegans and 50 omnivores will be recruited at the Erasme Hospital, Brussels.
Hypothesis
- Relative induced-hyperuricemia by the vegan diet is not associated with impaired
endothelial function if vitamin B12 and folic acid levels are normal.
- Quantification of oxidoreductase (XOR) isoforms varies according to the diet. Omnivores
present more xanthine oxidase (XO) than vegans in which the xanthine dehydrogenase (XD)
isoform is more prevalent.
- The vegan group has more favorable oxidant, metabolic and inflammatory profiles than the
omnivore group.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06052553 -
A Study of TopSpin360 Training Device
|
N/A | |
| Completed |
NCT05511077 -
Biomarkers of Oat Product Intake: The BiOAT Marker Study
|
N/A | |
| Recruiting |
NCT04632485 -
Early Detection of Vascular Dysfunction Using Biomarkers From Lagrangian Carotid Strain Imaging
|
||
| Completed |
NCT05931237 -
Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults
|
N/A | |
| Completed |
NCT04527718 -
Study of the Safety, Tolerability and Pharmacokinetics of 611 in Adult Healthy Volunteers
|
Phase 1 | |
| Terminated |
NCT04556032 -
Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women
|
N/A | |
| Completed |
NCT04998695 -
Health Effects of Consuming Olive Pomace Oil
|
N/A | |
| Completed |
NCT04065295 -
A Study to Test How Well Healthy Men Tolerate Different Doses of BI 1356225
|
Phase 1 | |
| Completed |
NCT04107441 -
AX-8 Drug Safety, Tolerability and Plasma Levels in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT01442831 -
Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects
|
Phase 1 | |
| Terminated |
NCT05934942 -
A Study in Healthy Women to Test Whether BI 1358894 Influences the Amount of a Contraceptive in the Blood
|
Phase 1 | |
| Recruiting |
NCT05525845 -
Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
|
N/A | |
| Completed |
NCT05515328 -
A Study in Healthy Men to Test How BI 685509 is Processed in the Body
|
Phase 1 | |
| Completed |
NCT04967157 -
Cognitive Effects of Citicoline on Attention in Healthy Men and Women
|
N/A | |
| Completed |
NCT05030857 -
Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects
|
Phase 1 | |
| Recruiting |
NCT04714294 -
Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of HPP737 in Healthy Volunteers
|
Phase 1 | |
| Recruiting |
NCT04494269 -
A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls
|
Phase 1 | |
| Completed |
NCT04539756 -
Writing Activities and Emotions
|
N/A | |
| Recruiting |
NCT04098510 -
Concentration of MitoQ in Human Skeletal Muscle
|
N/A | |
| Completed |
NCT03308110 -
Bioavailability and Food Effect Study of Two Formulations of PF-06650833
|
Phase 1 |