Healthy Clinical Trial
Official title:
6 Week Feeding Study of Interactions Between Fibre and Polyphenols Sources on Colonic Phenolic Acid Production and Biomarkers of Health
Verified date | March 2023 |
Source | University of Glasgow |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The investigators have studied the acute interactions of polyphenols and NDC in a single meal in a human study containing tomatoes, lovage & onions, with and without inulin. The investigators now wish to study the longer-term interactions of these foods over 6 weeks as well as their impact on biomarkers of human health, the gut microbiome, human proteome and markers of risk of chronic disease. This may allow better targeted evaluation of foods which influence health through the gut microbiome.
Status | Completed |
Enrollment | 90 |
Est. completion date | September 30, 2019 |
Est. primary completion date | July 30, 2019 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 70 Years |
Eligibility | Inclusion Criteria: - Generally healthy - BMI>=25 - Not on antibiotics within 3 months of starting of study - No medication likely to influence gut function, colonic bacterial activity. Exclusion Criteria: - Antibiotics - Pregnancy - lactation |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Glasgow | Glasgow | Scotland |
Lead Sponsor | Collaborator |
---|---|
University of Glasgow | Scottish Universities Environmental Research Centre |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change from baseline of total amount of phenolic acids (umoles/24 hours) in urine (3 wk) | Profile and amounts of phenolic acids in urine derived from the colonic bacterial metabolism of polyphenols | 3 weeks | |
Primary | Change from baseline of total amount of phenolic acids (umoles/24 hours) in urine (6 wk) | Profile and amounts of phenolic acids in urine derived from the colonic bacterial metabolism of polyphenols | 6 weeks |
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