Healthy Clinical Trial
Official title:
The Effect of Protein Timing and Resistance Exercise on Lipolysis and Fat Oxidation in Resistance-Trained Women
NCT number | NCT03573687 |
Other study ID # | NPRO |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | March 20, 2017 |
Est. completion date | February 28, 2018 |
Verified date | July 2018 |
Source | Florida State University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The extent to which resistance exercise training and protein timing effects localized (belly fat) and systemic (whole body) fat metabolism in resistance-trained women is unknown. Therefore, this study will assess subcutaneous abdominal adipose tissue lipolytic rate and whole body substrate utilization over the course of two trials: 1) consuming casein protein during the day, and 2) consuming casein protein at night, before bed.
Status | Completed |
Enrollment | 13 |
Est. completion date | February 28, 2018 |
Est. primary completion date | February 28, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 35 Years |
Eligibility |
Inclusion Criteria: - Healthy - Resistance-trained (able to squat 1.0 times their body weight, and bench press 0.75 times body weight, adapted from ACSM Guidelines and piloted in our laboratory) - Normal weight (BMI = 18.5-25 kg/m2; body fat <33%) - Normally menstruating (on or off oral contraceptives) - Females. Exclusion Criteria: - Uncontrolled thyroid dysfunction (not on medication) - Musculoskeletal disorders - Currently smoke - Have milk allergies - Currently take medications or supplements known to affect substrate metabolism. |
Country | Name | City | State |
---|---|---|---|
United States | Institute for Sports Sciences and Medicine, Florida State University | Tallahassee | Florida |
Lead Sponsor | Collaborator |
---|---|
Florida State University |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Lipolysis | Lipolysis is the way that fat cells mobilize the stored fat to enter into blood circulation. Lipolysis can be measured using a technique called microdialysis. In short, a semi-permeable probe is inserted into the subcutaneous abdominal adipose tissue (SCAAT, or belly fat). Saline combined with a minute amount of ethanol is perfused into the SCAAT, and interstitial fluid is collected out. The concentration of ethanol in the interstitial fluid sample is an indicator of blood flow within the tissue. Glycerol and free fatty acid concentration is measured to indicated rate of fat metabolism (specifically glycerol). The area under the curve for glycerol concentration over time (AUCgly) will be calculated for each of time point. Microdialysis dialysate samples will be measured during the NP and DP trials at fifteen separate time points throughout each visit. | 18 hours | |
Secondary | Hormone Concentrations | Serum samples will be analyzed for the assessment of glucose, insulin, and growth hormone on collections 1, 3, 4, and 5. Serum glycerol will be assessed at 5 time points. Serum catecholamines will be assessed at time points 1, 2 and 3. The timeline for blood collections is as follows: During microdialysis probe equilibration (~1600 hours); Half way through the RT protocol (~1800 hours, after the third exercise: Romanian deadlift) Thirty minutes after daytime supplement (1900 hours); Thirty minutes after nighttime supplement (2300 hours), and; The following morning after RMR (0750 hours) |
18 hours | |
Secondary | Fat oxidation | Fat oxidation is when those stored fats enter into the muscle cells and are able to be oxidized to form energy. Fat oxidation will be quantified by measuring resting metabolic rate (RMR, amount of calories burned at rest) and respiratory exchange ratio (RER, measure of whole-body substrate utilization) using a dilution technique and open-circuit indirect calorimetry (ParvoMedics TrueOne 2400 metabolic cart, Sandy, UT). This technique uses a ventilated hood covering the participants' head and torso. Participants will be asked to remain awake, quiet, and as motionless as possible in a semi-recumbent position in a quiet, dark, climate-controlled isolated room (20-23°C). Resting metabolism will be measured on four separate occasions. | 18 hours |
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