Healthy Clinical Trial
Official title:
The Impact of Enteral Versus Oral Protein Feeding on Muscle Protein Synthesis in Healthy Young Males and Females
Verified date | December 2018 |
Source | University of Exeter |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The present study will seek to quantify the muscle protein synthetic response to a protein beverage consumed orally or through a nasogastric tube in healthy, young individuals.
Status | Completed |
Enrollment | 30 |
Est. completion date | December 1, 2018 |
Est. primary completion date | December 1, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility |
Inclusion Criteria: - 18-40 years of age - Body mass index between 18.5 and 30 Exclusion Criteria: - Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes) - Any diagnosed cardiovascular disease - Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of =140 mmHg over two or more measurements and an average diastolic blood pressure of =90 mmHg over two or more measurements) - Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism). This excludes oral contraceptives and contraceptive devices. - A personal or family history of epilepsy, seizures or schizophrenia. - Presence of an ulcer in the stomach or gut and/or strong history of indigestion - Known pre-existing liver disease/condition - Any known disorders in muscle metabolism - Regular use of nutritional supplements - Allergy to lidocaine - Allergy to milk - Current paracetamol use (i.e. use of paracetamol more than once a week) - Pregnancy |
Country | Name | City | State |
---|---|---|---|
United Kingdom | University of Exeter | Exeter | Devon |
Lead Sponsor | Collaborator |
---|---|
University of Exeter |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Postprandial muscle protein synthesis | Muscle protein synthesis rate (FSR) following ingestion of a placebo or protein supplement | 5 hours | |
Secondary | Postabsorptive muscle protein synthesis | Muscle protein synthesis rate (FSR, in %/h) during a 2 hour fasting period | 2 hours | |
Secondary | Whole-body protein synthesis | Whole-body protein synthesis, measured using a D5 phenylalanine and D2 tyrosine infusion (umol Phenylalanine/kg/h) | 7 hours | |
Secondary | Whole-body protein breakdown | Whole-body protein breakdown, measured using a D5 phenylalanine and D2 tyrosine infusion (umol Phenylalanine/kg/h) | 7 hours | |
Secondary | Whole-body protein oxidation | Whole-body protein oxidation, measured using a D5 phenylalanine and D2 tyrosine infusion (umol Phenylalanine/kg/h) | 7 hours | |
Secondary | Whole-body protein net balance | Whole-body protein net balance, measured using a D5 phenylalanine and D2 tyrosine infusion (umol Phenylalanine/kg/h) | 7 hours | |
Secondary | Gastric emptying rate | Gastric emptying rate following ingestion of a placebo or protein drink | 5 hours | |
Secondary | Blood glucose concentration | Blood glucose concentration in the postabsorptive and postprandial phase following placebo/protein ingestion | 8.5 hours | |
Secondary | Serum insulin concentration | Serum insulin concentration in the postabsorptive and postprandial phase following placebo/protein ingestion | 8.5 hours |
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