High Nucleotide Meal Consumption in Uric Acid and Metabolic Health

Healthy Clinical Trial

— TIDE  

Official title:

The Acute Effect of a High Nucleotide Mycoprotein Meal in Uric Acid Concentrations and Other Markers of Health

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03568864
• Other study ID #: 170712/A/01
• Status: Completed
• Phase: N/A
• Start date: July 31, 2017
• Est. completion date: March 14, 2018

Study information

• Verified date: June 2018
• Source: University of Exeter
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The production of protein rich animal products is associated with a large environmental burden, and with ethical considerations. Additionally, the over-consumption of meat might be associated with detrimental effects to health.

Using mycoprotein, a food ingredient derived from the fermentation of a fungus, as a meat substitute could result in environmental benefits, and could have a role in managing obesity, diabetes and improving metabolic health. However, naturally produced mycoprotein has a high nucleotide content and little is known about the impact of nucleotides in uric acid levels and other health markers.

The aim of this study is to investigate the effect of a meal based on nucleotide rich mycoprotein on uric acid concentrations and other markers of health.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 10
• Est. completion date: March 14, 2018
• Est. primary completion date: March 14, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• BMI between 18 and 30

Exclusion Criteria:

• On medication (except contraception)

• Smokers

• Diagnosed with any metabolic or cardiovascular conditions

• BMI < 18 or > 30

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Low nucleotide meal
The participants will consume a mixed meal (sandwich) containing a nucleotide depleted mycoprotein product (low in nucleotides)
• High nucleotide meal
The participants will consume a mixed meal (sandwich) containing a non nucleotide depleted mycoprotein product (high in nucleotides)

Locations

Country	Name	City	State
United Kingdom	St Luke's Campus - University of Exeter	Exeter	Devon

Sponsors (1)

Lead Sponsor	Collaborator
University of Exeter

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes in serum uric acid concentrations over a 24 h period		Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 8, 12 and 24 hours after meal
Secondary	Blood glucose		Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 24 hours after meal
Secondary	Serum insulin		Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal
Secondary	Branched chained amino-acids		Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal