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Effect of Methylenedioxymethamphetamine (MDMA) (Serotonin Release) on Fear Extinction — MFE  

Healthy Clinical Trial

Official title:
Effect of MDMA (Serotonin Release) on Fear Extinction

Clinical Trial Summary

Serotonin and oxytocin play a role in fear conditioning and fear extinction learning, psychological processes that are critically involved in psychiatric disorders such as posttraumatic stress disorder (PTSD). Specifically, administration of oxytocin has been shown to facilitate fear extinction in humans. Similarly, substances that release serotonin and oxytocin such as MDMA have been shown to enhance the extinction of fear memory in animals. However, there are no data on the effects of MDMA on fear extinction in humans. Therefore, the primary aim of this study is to investigate the role of acute serotonin release in the effects of fear extinction. MDMA will be used as pharmacological tool to induce serotonin release in this study.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03527316
Study type Interventional
Source University Hospital, Basel, Switzerland
Contact
Status Completed
Phase Early Phase 1
Start date October 18, 2019
Completion date December 24, 2020
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