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Oxytocin Administration and Emotion Recognition Abilities in Adults Reporting Adverse Childhood Experiences

Healthy Clinical Trial

Official title:
Long-term Consequences of Childhood Adversity: Exploring Stress Responsive Molecular Pathways and Psychobiological Intervention Models

Clinical Trial Summary

This study evaluates whether intranasal administration of a single dose of oxytocin improves the ability to recognize emotional states. In a cross-over design, half of the participants first received oxytocin, the other half first received placebo.

Clinical Trial Description

Adverse childhood experience such as neglect or abuse can lead to long-term deficits in emotion processing abilities, and these effects might be mediated via alterations in oxytocin production or sensitivity. The goal of this study was to test whether emotion recognition abilities and empathy might be improved by intranasal oxytocin administration in adults with a history of childhood maltreatment.

In a double-blind, placebo-controlled experiment with a crossover design, we assessed the performance of 40 healthy participants with a history of childhood adversity on the Reading the Mind in the Eyes Test (RMET) and an emotion recognition task under 24 IU oxytocin vs. placebo and compared them to a control group of 40 matched individuals without traumatic childhood experiences. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03335085
Study type Interventional
Source Ruhr University of Bochum
Contact
Status Completed
Phase N/A
Start date July 1, 2011
Completion date November 5, 2013
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