"Beverage Hydration Index" of Commercial Therapeutic Beverages

Healthy Clinical Trial

Official title:

Beverage Hydration Index of Three Commercial Oral Rehydration Therapy ORT Beverages

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03262597
• Other study ID #: IRB Application #2667
• Status: Completed
• Phase: N/A
• First received: August 23, 2017
• Last updated: March 5, 2018
• Start date: February 17, 2017
• Est. completion date: April 14, 2017

Study information

• Verified date: March 2018
• Source: Sonoma State University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The "beverage hydration index" (BHI) assesses the hydration potential of any consumable fluid relative to water. The BHI is a relatively new metric. Our purpose was to assess the BHI of beverages never previously tested, including an amino acid-based oral rehydration solution (AA-ORS), a glucose-containing ORS (G-ORS) and a sports drink (SD) compared to water (control).

Description:

The "Beverage Hydration Index" (BHI) was created to assess the degree to which beverages "hydrate", by measuring fluid retention after ingesting a 1 liter bolus and comparing it to water. Drinks with carbohydrates and electrolytes would traditionally be expected to score higher on the BHI due to glucose-sodium cotransport at the gut and osmolality approaching isotonicity with blood. One recent study reported that an oral rehydration solution (ORS) scored better than water, but a "sports drink" did not. No "optimal" BHI beverage composition has been described, nor has an optimal osmolality. Recently, a hypotonic amino acid-based rehydration beverage was developed to take advantage of amino acid-sodium cotransport, thus obviating the need for carbohydrate. However, the BHI of this beverage has not yet been assessed. The purpose of this investigation was to assess the hydration potential of this novel beverage in comparison to a commercially available carbohydrate-containing sports drink and oral rehydration solution.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 46
• Est. completion date: April 14, 2017
• Est. primary completion date: April 14, 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 35 Years

Eligibility

Inclusion Criteria:

• Healthy male or female

• Aged 18-35

• BMI 18-27 kg/m2

• No known cardiovascular, renal or metabolic disease

• Moderately active

• Moderate alcohol use

Exclusion Criteria:

• Overweight or obese (BMI >27 kg/m2)

• Competitive athletes during competition season

• Current or former cardiovascular, renal or metabolic disease

• Habitual consumption of alcohol (>21 units/week) or regular (>1/week) high (10 units) intake*

• History of psychiatric illness

• Actively seeking to gain or lose weight

• Currently taking prescribed medication

• Example, a 750 ml bottle of wine at 12% ABV contains 0.750 Liters * 12 = 9 units

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• enterade
Subjects will consume enterade, which is an amino acid-based oral rehydration solution.
• Pedialyte
Subjects will consume Pedialyte
• Gatorade
Subjects will consume Gatorade
• Water
Subjects will consume water as the control beverage

Locations

Country	Name	City	State
United States	Sonoma State Univrsity	Rohnert Park	California

Sponsors (2)

Lead Sponsor	Collaborator
Sonoma State University	Entrinsic Health Solutions, Inc.

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Beverage hydration index	beverage hydration index	4 hours