Healthy Clinical Trial
Official title:
Functional Magnetic Resonance Imaging of Human Hypothalamic Responses to Glucose, Fructose, Sucrose and Sucralose
Verified date | August 2017 |
Source | Unilever R&D |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The study will consist of five occasions with one week in between. BOLD signal intensity of the hypothalamus will be measured using fMRI. Measurements will be done before and after drinking 300 ml plain water (reference) or water to which different sweeteners will be added.
Status | Completed |
Enrollment | 16 |
Est. completion date | May 22, 2015 |
Est. primary completion date | May 22, 2015 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 25 Years |
Eligibility |
Inclusion Criteria: - Signed informed consent - Age between 18 and 25 years - BMI between 20 and 24 kg/m2 - Length between 170 and 190 centimetres Exclusion Criteria: - Diabetes or history of other disturbances of glucose metabolism (eg impaired glucose tolerance, hypoglycaemia). - Any genetic or psychiatric disease (e.g. fragile X syndrome, major depression) affecting brain - Any significant chronic disease - Renal or hepatic disease - Recent weight changes or attempts to lose weight (> 3 kg weight gain or loss, within the last 3 months) - Smoking (current or last 6 months) - Alcohol consumption of more than 21 units per week or use of recreational drugs at present or in the last year - Recent blood donation (within the last 2 months) - Recent participation in other biomedical research projects (within the last 3 months), participation in 3 or more biomedical research projects in one year - Contra-indication to MRI scanning: - Claustrophobia - Pacemakers and defibrillators - Nerve stimulators - Intracranial clips - Intraorbital or intraocular metallic fragments - Cochlear implants - Ferromagnetic implants |
Country | Name | City | State |
---|---|---|---|
Netherlands | Leids Universitair Medisch Centrum | Leiden | Zuid-Holland |
Lead Sponsor | Collaborator |
---|---|
Unilever R&D | Leiden University Medical Center |
Netherlands,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Hypothalamic function in response to glucose, fructose, sucrose, and sucralose | fMRI will be performed before and after ingestion | Change from baseline (measured during 5 minutes before start of dinking) to post consumption (measured during 12 minutes after drinking). Drinking took 4 minutes. |
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