Healthy Clinical Trial
Official title:
Effects of Transcranial Direct Current Stimulation Over the Left Ventrolateral Prefrontal Cortex on Cognitive Reappraisal
Verified date | May 2020 |
Source | Universidade Federal de Pernambuco |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
This study aims to investigate the role of the left ventrolateral prefrontal cortex (VLPFC)
on cognitive reappraisal, using the reinterpretation strategy. For this purpose, we will
produce direct disturbance to the activity of this area through anodal and cathodal
transcranial direct current stimulation during a reinterpretation task.
A double-blind randomized sham-controlled trial will be conducted. 60 healthy volunteers will
be allocated into three groups. Each group will receive one type of stimulation (anodal,
cathodal or sham) while accomplishing a cognitive task on reinterpretation using images from
the International Affective Pictures System (IAPS). The task consists in applying a given
emotional regulation condition (downregulate, upregulate or maintain emotions) to a series of
images and ranking the intensity of the emotional arousal felt after doing this procedure to
each picture. The effects of tDCS on the subjective evaluation of emotional arousal after
reinterpretation in each group will be compared.
Status | Completed |
Enrollment | 60 |
Est. completion date | October 31, 2017 |
Est. primary completion date | June 28, 2017 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - graduate and post-graduate students at UFPE - aged > 18 years-old Exclusion Criteria: - seizures antecedent - brain tumor - neurosurgery antecedent - metalic implant on the head - cardiac pacemaker - current psychotropic usage - SRQ-20 score > 5 - ASSIST 3.0 (sum from 2-7 questions) > 10 for alcohol or > 3 for other drugs - left-handed |
Country | Name | City | State |
---|---|---|---|
Brazil | Applied Neuroscience Laboratory | Recife | Pernambuco |
Brazil | Federal University of Pernambucano | Recife | Pernambuco |
Lead Sponsor | Collaborator |
---|---|
Universidade Federal de Pernambuco |
Brazil,
Cattaneo Z, Pisoni A, Papagno C. Transcranial direct current stimulation over Broca's region improves phonemic and semantic fluency in healthy individuals. Neuroscience. 2011 Jun 2;183:64-70. doi: 10.1016/j.neuroscience.2011.03.058. Epub 2011 Apr 6. — View Citation
Cohen-Maximov T, Avirame K, Flöel A, Lavidor M. Modulation of Gestural-verbal Semantic Integration by tDCS. Brain Stimul. 2015 May-Jun;8(3):493-8. doi: 10.1016/j.brs.2014.12.001. Epub 2014 Dec 11. — View Citation
Feeser M, Prehn K, Kazzer P, Mungee A, Bajbouj M. Transcranial direct current stimulation enhances cognitive control during emotion regulation. Brain Stimul. 2014 Jan-Feb;7(1):105-12. doi: 10.1016/j.brs.2013.08.006. Epub 2013 Sep 21. — View Citation
Ochsner KN, Ray RD, Cooper JC, Robertson ER, Chopra S, Gabrieli JD, Gross JJ. For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion. Neuroimage. 2004 Oct;23(2):483-99. — View Citation
Pisoni A, Papagno C, Cattaneo Z. Neural correlates of the semantic interference effect: new evidence from transcranial direct current stimulation. Neuroscience. 2012 Oct 25;223:56-67. doi: 10.1016/j.neuroscience.2012.07.046. Epub 2012 Jul 31. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | ERQ Questionnaire score | The scores for the use of both strategies - reappraisal and suppression in the ERQ questionnaire | 20 minutes | |
Primary | Subjective Emotional Arousal Rating | The rating from 1-7 (1=very weak; 7=very strong) of the negative emotional arousal felt by the volunteer after the volunteer after using the reappraisal strategy for each picture. | 20 minutes | |
Secondary | Self-evaluation about the success in performing cognitive task | Self-evaluation of success in performing adequately the cognitive task in a 1-9 likert scale (0=no success; 9=total success) | 20 minutes |
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