Effects of Polyphenols Supplementation on Cycling Endurance

Healthy Clinical Trial

Official title:

Effects of Acute Specific Grape and Apple Polyphenols Supplementation on Cycling Endurance Performance

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03214276
• Other study ID #: CEN1143
• Status: Completed
• Phase: N/A
• First received: July 6, 2017
• Last updated: July 7, 2017
• Start date: January 1, 2012
• Est. completion date: July 1, 2012

Study information

• Verified date: July 2017
• Source: University of Burgundy
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Endurance performance during high intensive exercises is mainly determined by the capacity of the aerobic metabolism. It generally induces muscle fatigue defined as the reversible decline in skeletal muscle contractile performance. Fatigue is multifactorial and is often associated with many physiological parameters including reduced neural input and disruptive metabolic changes in skeletal muscles such as lactic acidosis and the production of oxidative free radicals. Moreover, it could lead to oxidative stress as a result of an imbalance between reactive oxygen species (ROS) production and intrinsic antioxidant defense.

To alleviate oxidative stress, some ergogenic strategies have been tested. Numerous studies have reported that different types of supplementation such as selenium, vitamin E, vitamin C or polyphenols were of interest to protect against these mechanisms. Indeed, although some studies demonstrated no or harmful effects, most studies observed positive effects of antioxidants on oxidative stress or performance. More particularly, polyphenols, have great antioxidant capabilities and protective effects and it increases the synthesis and bioavailability of nitric oxide (NO)which is well known to be the most important mediator of vasodilation. To date, most of the studies exploring the effects of polyphenols on exercise investigated several days or weeks of supplementations on vascular, blood parameters (blood pressure, NO concentration, oxidative stress markers) or endurance performance. Conflicting results are often obtained. Only few studies investigated the effects of a single intake on immediate performance and recovery capacity. Therefore, the present work aimed to study the effects of an acute intake of a specific profile polyphenols from grape and apple on physical performances. More specifically, performance, in the present study, referred to high intensity cycling exercise until exhaustion revealing the capacity to maintain a constant strong effort hereafter named endurance. The hypothesis was that an acute of polyphenols would increase the time to exhaustion during a high intensity cycling exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 48
• Est. completion date: July 1, 2012
• Est. primary completion date: June 1, 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 25 Years to 45 Years

Eligibility

Inclusion Criteria:

• Body mass index lower than 27 and waist size lower than 94 cm

• physical activity higher than 2 hours a week

• written informed consent

Exclusion Criteria:

• more than 6 hours training a week, regularly trained in aerobic activities

• asthmatic, smokers or under medicinal drugs

• dietary supplement, sports drink, special dietary food or functional food, of any kind, liable or presented as liable to enhance physical performances

Related Conditions & MeSH terms

• Healthy

Intervention

Dietary Supplement:
• Vinitrox polyphenols
Vinitrox™ (Nexira - France) is a combination of specific profile polyphenols from grape and apple. The main polyphenol classes are proanthocyanidins (as catechins, B2 dimer), phenolic acids (as chlorogenic acids, gallic acids) and anthocyanins (as malvidin-3-glucoside). It was administrated the night and the morning before the endurance test (oral administration)
• Placebo
Made with maltodextrin. It was administrated the night and the morning before the endurance test (oral administration).

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Burgundy

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Time to exhaustion	Maximal duration during a cycling aerobic exercise (70% of maximal aerobic power)	The total duration of the aerobic exercise (during the cycling aerobic exercise)
Secondary	Heart rate	Heart rate using a polar belt	Immediately before the endurance test, immediately after the endurance test and continuously recorded during three minutes during the recovery to determine half-recovery time
Secondary	Gaz exchange	oxygen intake using a portable gaz exchange analyzer	Immediately before the endurance test, immediately after the endurance test and continuously recorded during three minutes during the recovery to determine half-recovery time
Secondary	blood pressure	blood pressure measured at the arm	Immediately before the endurance test, immediately after the endurance test
Secondary	Pain sensation	Pain sensation using a visual analog scale	Immediately after the endurance exercise and 48 hours after the endurance test