Healthy Clinical Trial
Official title:
the Regulation of Phosphorus Homeostasis by Dietary Phosphorus Intake in Normal Men
The investigators have conducted the study about the effects of normal diet and low-phosphorus diet on phosphorus homeostasis in healthy subjects, now this study is designed to explore further about the effect of high-phosphorus diet on phosphorus homeostasis.
Serum phosphate concentrations are not only associated with cardiovascular and all-cause
mortality in chronic kidney disease (CKD) patients, but also associated with the mortality in
community population. Thus, maintaining normal serum phosphate and reducing postprandial
fluctuation of serum phosphate are essential for healthy people.
The investigators have conducted a study about the effects of normal diet (phosphorus 1500mg)
and low-phosphorus diet (phosphorus 500mg) on phosphorus homeostasis in healthy men. The
results showed low-phosphorus diet could significantly reduce serum phosphorus and urine
phosphorus level compared to normal diet. However, the levels of serum FGF23 and a-klotho
were not different between these two groups.Thus, the investigators want to further explore
the effects of high-phosphorus diet (phosphorus 2300mg)on phosphorus homeostasis in healthy
men.
Therefore, the investigators plan to conduct a crossover clinical study to evaluate the
phosphorus homeostasis modulated by native normal diet, restricted phosphorus diet, high
phosphorus diet and then to explore the underlying mechanisms.
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