Healthy, Young Adults Clinical Trial
Official title:
Effects of Remote Limb Ischemic Conditioning to Enhance Performance, Cognitive-motor Learning and Muscle Strength in Healthy Young Adults
The purpose of this research study is to determine if remote limb ischemic conditioning (RLIC) can enhance learning of a motor (balance) and an ecologically valid, complex cognitive-motor (driving) task, and increase skeletal muscle strength in neurologically-intact young adults.
Ischemic conditioning is an endogenous phenomenon in which exposing a target organ or tissue
to one or more brief episodes of ischemia results in protection of that organ against
subsequent ischemia. The effects of ischemic conditioning are not confined within an organ
but can be can be transferred from one organ to another, a technique called remote ischemic
conditioning. A clinically feasible method for this is remote limb ischemic conditioning
(RLIC), where episodes of ischemia and perfusion are induced with a blood pressure cuff
placed on the arm.
The overall goal of this line of work is to use ischemic conditioning to enhance learning and
outcomes in persons with neurologic injuries. Two previous studies have shown that remote
limb ischemic conditioning (RLIC) can enhance learning a motor task in healthy young adults.
The current study extends that work to determine if RLIC enhances muscle strength training
and a complex cognitive-motor task (simulated driving). This Phase I study will yield the
necessary information to design and execute subsequent trials in neurologic patient
populations.
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| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT03512041 -
Effect of Number of Remote Limb Ischemic Conditioning Cycles on Learning Enhancement
|
Phase 1 |