Healthy Volunteers Clinical Trial
Official title:
Brain During Effort : Effects of Hypoxia With Respiratory Patients
Brain oxygenation is determined by the product of CaO2 and the cerebral blood flow (CBF), the
modification of one or the other can affect the neuronal O2 availability.
Besides the effect of the PaO2, the CBF is also regulated by the PaCO2. During effort in
state of hypoxia, the drop of the PaO2 associated to a potential decrease of the PaCO2 and
therefore of the CBF, can create an important dizziness between the demand and the supply of
cerebral O2.
It seems that hypoxia can trouble in a significant way the response of central neurons, just
as the production of a motor cortex generated motor command.
Studies suggest that exercise in severe hypoxia condition can constitute a necessary threat
for brain oxygenation and the motor command, with the consequence a decrease of the exercise
performance.
This projects aim to study effects of hypoxia on the brain function for patients suffering
from chronic respiratory disease. Neurophysiologic responses of the brain while resting or
exercising, including drip and cerebral oxygenation, cortical excitation and motor command
resulting for hypoxic subjects before and after a treatment to correct abnormalities of gaz
in blood.
The study will use a multidisciplinary and supplementary methodological approach : the
near-infrared spectroscopy (NIRS) to appreciate the drip and cerebral oxygenation, CBF,
neurostimulation procedures and electromyography (EMG) to appreciate the cortical
excitability, measure the level of central activation and motor command.
The goals of this study will be :
- Measure the drip and cerebral oxygenation, the cortical excitability, mechanisms of
voluntary activation and central fatigue to the effort for the chronic hypoxemic patient
compared to healthy control subjects.
- Analyse disruptions of locomotion parameters and posturographyc, in simple and double
task, involving different levels of cerebral task.
- Analyse acute effects of an improvement of arterial oxygenation for patients suffering
from chronic obstructive pulmonary disease (COPD) on drip and cerebral oxygenation,
cortical excitability, mechanisms of voluntary activation and central fatigue.
- Evaluate effects of a treatment by continuous positive airway pressure (CPAP) for
patients suffering from obstructive sleep apnea (OSA) with the same parameters.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05029518 -
3-Way Crossover Study to Compare the PK (Pharmokinetics) and to Evaluate the Effect of Food on the Bioavailability
|
Phase 1 | |
| Completed |
NCT05001152 -
Taste Assessment of Ozanimod
|
Phase 1 | |
| Completed |
NCT04493255 -
A Study to Determine the Metabolism and Elimination of [14C]E7090 in Healthy Male Participants
|
Phase 1 | |
| Completed |
NCT03457649 -
IV Dose Study to Assess the Safety, Tolerability, PK, PD and Immunogenicity of ARGX-113 in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT00995891 -
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies
|
||
| Completed |
NCT05050318 -
Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2021-2022 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively
|
Phase 4 | |
| Completed |
NCT05043766 -
Evaluation of Oral PF614 Relative to OxyContin
|
Phase 1 | |
| Completed |
NCT04466748 -
A Multiple Ascending Dose Pharmacology Study of Anaprazole in Healthy Chinese Subjects
|
Phase 1 | |
| Completed |
NCT00746733 -
Vyvanse and Adderall XR Given Alone and in Combination With Prilosec OTC
|
Phase 1 | |
| Recruiting |
NCT05929651 -
Study of Immunogenicity and Safety of MenQuadfi® as a Booster Vaccine in Toddlers 12 to 23 Months, Regardless of the Quadrivalent Meningococcal Conjugate Vaccine Used for Priming in Infancy
|
Phase 4 | |
| Completed |
NCT05954039 -
Evaluation of the Efficacy of a Dietary Supplement on Hair Loss and Hair Aspect
|
N/A | |
| Completed |
NCT05045716 -
A Study of Subcutaneous Lecanemab in Healthy Participants
|
Phase 1 | |
| Active, not recruiting |
NCT02747927 -
Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children
|
Phase 3 | |
| Completed |
NCT05533801 -
A Study to Demonstrate the Bioequivalence of Lecanemab Supplied in Vials and a Single-Use Auto-Injector (AI) in Healthy Participants
|
Phase 1 | |
| Not yet recruiting |
NCT03931369 -
Adaptation of Thirst to a Single Administration of Tolvaptan (TOLVATHIRST)
|
Phase 2 | |
| Completed |
NCT03279146 -
A Single Dose Study Evaluating PK of TXL Oral Formulations in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT06027437 -
A Study to Assess the Relative Biological Availability and the Effect of Food on the Drug Levels of Danicamtiv in Healthy Adult Participants
|
Phase 1 | |
| Recruiting |
NCT05619874 -
Effects of Two Virtual HIFCT Programs in Adults With Abdominal Obesity
|
N/A | |
| Completed |
NCT05553418 -
Investigational On-body Injector Clinical Study
|
N/A | |
| Completed |
NCT04092712 -
Study Evaluating Pharmacokinetics and Mass Balance of [14C]-CTP-543 in Healthy Adult Male Volunteers
|
Phase 1 |