Clinical Trials Logo

Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT05812651
Other study ID # REC/01375 Qurat ul ain Gohar
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date March 1, 2023
Est. completion date July 1, 2023

Study information

Verified date July 2023
Source Riphah International University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aim of study was to evaluate the effects of inspiratory induced muscle fatigue on functional mobility of older adults. Though, limited literature exists regarding inspiratory muscle fatigue and its consequences on functional activities of daily living and balance. Yet, it is not clear how improvement in inspiratory muscle strength is related with improvement in functional mobility.


Description:

Respiratory muscle fatigue was first described in 1977. Inspiratory muscle relaxation rates are known to slow following induction of fatigue. Inspiratory muscle fatigue was induced by threshold loading at 80 percent of (Maximum Inspiratory Pressure) Pimax until the subjects were unable to generate the target pressure. Inspiratory muscle fatigue (IMF) is proposed to negotiation exercise performance, probably via a respiratory muscle metaboreflex that impairs blood flow to working muscles, thereby accelerating the progress of fatigue in these muscles. Respiratory muscle fatigue revealed that a maximal inspiratory load of 50% could quickly fatigue both the inspiration and expiration muscles. Increased inspiratory muscle work may induce fatigue of the respiratory muscles, as well as of the non-respiratory muscles by central alterations at spinal and supraspinal level. Also there is an association between respiratory muscle dysfunction and physical performance in older adults. The abnormalities of respiratory movements may be dependable clinical signs of inspiratory muscle fatigue, mostly when accompanied by tachypnea and hypercapnia. Fatigue is distinguished from weakness, a decrease in force generation that is static and not reversible by rest, though muscle weakness may be a susceptibility to muscle fatigue. This study will contribute to determine the effects of respiratory muscle fatigue on balance and functional mobility with healthy older adults. To further understand this relationship, a battery of tests (considered as gold standard) will be performed after induced inspiratory muscles fatigue.


Recruitment information / eligibility

Status Completed
Enrollment 70
Est. completion date July 1, 2023
Est. primary completion date May 30, 2023
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 60 Years and older
Eligibility Inclusion Criteria: - Adults with age 60+ years - Both male and female participants - Patients with Forced Expiratory Volume 1/Forced Volume Capacity ratio greater than 80% Exclusion Criteria: - Smokers - Subjects with a history of cardiovascular, respiratory, or neuromuscular - Diseases that can impede test or alter the maximum inspiratory pressure. - Subjects with cognitive impairment. - Subjects with low back and musculoskeletal disorders. - Previous experience in respiratory muscle training.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Inspiratory muscle fatigue
Muscle training according to the protocol that tends to induce inspiratory muscle fatigue. (60-80% MIP). Inspiratory resistive loading by starting at 60-80% (MIP) increasing every 10 minutes by 10% then measure MIP, until MIP measurement decrease of more than 10% from baseline will be performed. When report a lower score of MIP and participants could no longer worked out, performed the functional mobility tests and see if there any variation.

Locations

Country Name City State
Pakistan Railway General Hospital Rawalpindi Punjab

Sponsors (1)

Lead Sponsor Collaborator
Riphah International University

Country where clinical trial is conducted

Pakistan, 

References & Publications (4)

Ferraro FV, Gavin JP, Wainwright T, McConnell A. The effects of 8 weeks of inspiratory muscle training on the balance of healthy older adults: a randomized, double-blind, placebo-controlled study. Physiol Rep. 2019 May;7(9):e14076. doi: 10.14814/phy2.14076. — View Citation

Giua R, Pedone C, Scarlata S, Carrozzo I, Rossi FF, Valiani V, Incalzi RA. Relationship between respiratory muscle strength and physical performance in elderly hospitalized patients. Rejuvenation Res. 2014 Aug;17(4):366-71. doi: 10.1089/rej.2014.1549. — View Citation

Seixas MB, Almeida LB, Trevizan PF, Martinez DG, Laterza MC, Vanderlei LCM, Silva LP. Effects of Inspiratory Muscle Training in Older Adults. Respir Care. 2020 Apr;65(4):535-544. doi: 10.4187/respcare.06945. Epub 2019 Oct 29. — View Citation

Watsford ML, Murphy AJ, Pine MJ. The effects of ageing on respiratory muscle function and performance in older adults. J Sci Med Sport. 2007 Feb;10(1):36-44. doi: 10.1016/j.jsams.2006.05.002. Epub 2006 Jun 30. — View Citation

Outcome

Type Measure Description Time frame Safety issue
Primary Six minute walk test The 6 Minute Walk Test is a sub-maximal exercise test used to assess aerobic capacity and endurance. After 3 days
Primary 30sec sit to stand test The 30 Second Sit to Stand Test is also known as 30 second chair stand test ( 30CST), is for testing leg strength and endurance in older adults. After 3 days
Primary Arm curl field test The Arm Curl Fitness Test for upper body strength using the bicep curl technique, a test designed of the functional fitness of seniors After 3 days
Primary Stair climbing test The stair climb test (also known as stair climb power test) is a clinically relevant, safe, and inexpensive field-based assessment of lower body strength, power, and physical function for older adults After 3 days
Secondary Physical activity scale for elderly (PASE) Physical Activity Scale for the Elderly (PASE) is a brief (5 minutes) and easily scored survey designed specifically to assess physical activity in epidemiological studies of persons age 65 years and older. The PASE assesses the types of activities typically chosen by older adults (walking, recreational activities, exercise, housework, yard work, and caring for others. It uses frequency, duration, and intensity level of activity over the previous week to assign a score, ranging from 0 to 793, with higher scores indicating greater physical activity After 3 days
See also
  Status Clinical Trial Phase
Recruiting NCT04181983 - Personalized Exercise Programs for Older Adults - a Digital User-friendly Application N/A
Withdrawn NCT01888055 - Influence of tDCS on Cortical Plasticity in Healthy Older Adults N/A
Completed NCT04608370 - Transcranial Photobiomodulation Intervention for Healthy Older Adults N/A
Completed NCT05874999 - Acute Effects of Supramaximal High-Intensity Interval Training in People With COPD N/A
Completed NCT02110056 - Modulation of Visual-Spatial Learning in Healthy Older Adults by tDCS N/A
Withdrawn NCT04353947 - Induction and Recognition of Emotions
Not yet recruiting NCT06284720 - Transcranial Alternating Current Stimulation for the Improvement of Episodic Memory in Healthy Older Adults N/A
Completed NCT02104999 - Technical Accuracy and Userfriendliness of a Point-Of-Care C Reactive Protein Device in a Nursing Home Setting N/A
Completed NCT01411059 - Yoga Empowers Seniors Study N/A
Completed NCT02346981 - Resistance Training and Post-exercise Blood Pressure in Normotensive Older Women N/A
Completed NCT03614182 - Effects of Simultaneous or Sequential Combination of Physical and Cognitive Training N/A
Completed NCT05134870 - Mimic-game & Groove: A TeleXercise Intervention to Get Active & Get Healthy N/A
Completed NCT03234998 - Comparative Efficacy of Two Different Dual-task Balance Interventions N/A
Active, not recruiting NCT03430401 - Computer-based Cognitive Rehabilitation Program for Healthy Older Adults, Older People With Mild Cognitive Impairment and Mild Dementia N/A
Completed NCT02794272 - tDCS Effects on GABA Concentration and Brain Functional Connectivity in Older Adults Of Working Age N/A
Completed NCT02794259 - tDCS Effects on GABA Concentration and Brain Functional Connectivity in Older Adults of Retirement Age N/A
Completed NCT02795702 - tDCS Effects on Associative Learning in Older Adults of Working Age N/A
Completed NCT02839993 - tDCS Effects on Associative Learning in Older Adults of Retirement Age N/A