Clinical Trials Logo

Clinical Trial Summary

The goal of this experimental study, with crossover design, is to analyze the effects of body lateralization applied at 30 degrees compared to the supine position on the distribution of ventilation and regional lung aeration in healthy individuals. The main study questions to be answered are: - Question 1: What are the immediate effects of 30 degree body lateralization on the distribution of regional ventilation and lung aeration in healthy individuals? - Question 2: What is the effect of body lateralization on diaphragmatic mobility in the dependent or non-dependent hemithorax? Participants will be submitted to changes in positioning in bed, considering a randomized sequence of interventions, between supine position and body lateralization at 30 degrees, using the Multicare bed (Linet, Czech Republic). The interventions were repeated twice each with a 30-minute washout in each sequence. Participants will perform assessment of lung function and respiratory muscle strength with the instruments: - Manovacuometry - Spirometry - Ventilometry - Respiratory Diagnostic Assistant The supine and body lateralization positions will be compared, with the primary outcomes being lung aeration and ventilation distribution assessed using Electrical Impedance Tomography. The secondary outcome will be diaphragmatic mobility measured through lung ultrasound. Groups: - Supine position - Body lateralization Effects - Lung aeration - Distribution of ventilation - Diaphragmatic mobility


Clinical Trial Description

Body positioning is a therapy used in the hospital environment to improve oxygenation. Recent studies recommend lateralization therapy to improve lung function locally by positioning the chest region of interest upwards. However, there are still gaps in the description of the effects of body lateralization on lung aeration and ventilation between non-dependent and gravity-dependent regions and on diaphragmatic mobility. The objective of this study is to analyze the acute effects of lateralization on the aeration and distribution of lung ventilation, in comparison with the supine position, in healthy subjects. In addition, the effect of body positioning on diaphragm kinetics was evaluated. This is a crossover study, which will be carried out at the Hospital das Clínicas of the Federal University of Pernambuco (HC-UFPE). The sample will consist of 30 healthy volunteers, aged between 18 and 59 years, of both sexes. The change of body position will be performed using the Multicare bed (Linet, Praga,Czech Republic). Lung ventilation and aeration will be evaluated with an Enlight 1800 electrical impedance tomography (EIT) (Timpel Medical, São Paulo, Brazil). The EIT images will be segmented into four regions of interest (ROIs: anterior right, anterior left, posterior right and posterior left. Diaphragm mobility will be quantified by diaphragmatic ultrasound in the supine and lateral positions. The study was approved by the Research Ethics Committee of the Hospital das Clínicas of the Federal University of Pernambuco (EBSERH), in accordance with the norms of the National Health Council (Resolution 466/12) for research in human beings (opinion number 5,980.254). ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06044896
Study type Interventional
Source University of Pernambuco
Contact
Status Completed
Phase N/A
Start date September 22, 2023
Completion date October 25, 2023

See also
  Status Clinical Trial Phase
Completed NCT02101801 - Urine Drug Levels Related to Source of Water for Irrigation for Vegetable Crops Among Healthy Israeli Volunteers N/A
Recruiting NCT06101641 - Effect of Shellac Nail Polish Application on Pulse Oximetry Measurements in Healthy Individuals N/A
Completed NCT03065283 - Effects of Diaphragm-releasing Techniques on the Lumbar Spine and Diaphragmatic Function in Healthy Women N/A
Recruiting NCT01721811 - Retinal Function in Relation to Transient or Chronic Challenges to Retinal Metabolism N/A
Completed NCT01211717 - The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients N/A
Completed NCT01568541 - Fluoride Intake From Toothbrushig With Children's or Regular Toothpastes N/A
Completed NCT04941196 - Bioequivalence Study of Anplag® 90mg (Ticagrelor) Tablet & Brilinta® 90 mg (Ticagrelor) Tablet in Healthy Adult Male Pakistani Subjects Under Fasting Condition Phase 1
Completed NCT05541094 - Study of Vitamin D Fortification of Milk and Oil
Completed NCT05597657 - Normal Variation of T1 Values With Cardiac Magnetic Resonance in Healthy Individuals N/A
Completed NCT03728868 - Tolerability and Risk of Adverse Events With a Probiotic Supplement N/A
Recruiting NCT04513782 - The Contributions of Age Related Changes in the Sound Localization Pathway to Central Hearing Loss
Completed NCT05637060 - Bioequivalence Study of Rosuvastatin Tablet N/A
Not yet recruiting NCT05110885 - Public AttitudesTowards SMA and DMD Awareness, Newborn and Carrier Screening and Physiotherapy Practices
Completed NCT01134978 - Neural Mechanisms of the Contextual Interference Effect: A fNIRs and EEG Study Phase 1
Completed NCT06137534 - Upper Extremity Pattern Exercises and Respiratory Functions N/A
Completed NCT04873570 - Bioequivalence Study of Mofest® 400mg (Moxifloxacin) Tablet With Avelox® 400mg (Moxifloxacin) Tablet in Healthy Pakistani Subjects Phase 1
Enrolling by invitation NCT01872091 - Analysis of Neuromuscular, Circulatory and Biomechanical Responses After Cryotherapy N/A
Completed NCT01872117 - Assessment of Temperature by Infrared Thermography and Blood Conduction Velocity by Doppler After Applying Shortwave Diathermy and Microwave - Correlations With Cardiovascular and Hemodynamic Parameters N/A
Completed NCT02409836 - A Study to Assess the Ingestion of Dentifrice by Children N/A
Recruiting NCT05358561 - Postprandial Glucose, Insulin and Subjective Saturation Response in Healthy Individuals N/A