Clinical Trials Logo

Clinical Trial Summary

The purpose of the study is to determine the normal variation of T1 values with cardiac magnetic resonance in healthy individuals with respect to reproducibility, changes over time, and dependency on hydration status.


Clinical Trial Description

T1 mapping with cardiac magnetic resonance (CMR) is a novel non-invasive technique to quantitatively characterize the myocardium. T1 mapping is a surrogate marker of myocardial edema and fibrosis, and has the potential to be implemented in the diagnosis and follow-up of various cardiac diseases. However, there is limited data on the natural variation of T1 mapping in healthy individuals. The study comprises three substudies: 1. Reproducibility: Two identical CMR examinations with T1 mapping will be performed on the same day . 2. Hydration changes: Participants will receive two liters of isotonic saline intravenously between two identical CMR with T1 mapping and echocardiographic examinations. The post-fluid order of CMR and echocardiography will be randomized. 3. Time changes: Participants will undergo CMR with T1 mapping at baseline, at 6-months follow-up, and at 1-year follow-up. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05597657
Study type Interventional
Source Rigshospitalet, Denmark
Contact
Status Completed
Phase N/A
Start date October 12, 2021
Completion date September 15, 2023

See also
  Status Clinical Trial Phase
Completed NCT06044896 - Physiology of Body Lateralization on Regional Lung Ventilation Study N/A
Completed NCT02101801 - Urine Drug Levels Related to Source of Water for Irrigation for Vegetable Crops Among Healthy Israeli Volunteers N/A
Recruiting NCT06101641 - Effect of Shellac Nail Polish Application on Pulse Oximetry Measurements in Healthy Individuals N/A
Completed NCT03065283 - Effects of Diaphragm-releasing Techniques on the Lumbar Spine and Diaphragmatic Function in Healthy Women N/A
Recruiting NCT01721811 - Retinal Function in Relation to Transient or Chronic Challenges to Retinal Metabolism N/A
Completed NCT01211717 - The Effects of Orally Ingesting Branched Chained Amino Acids on Delayed Onset Muscle Soreness in Diabetic Patients N/A
Completed NCT01568541 - Fluoride Intake From Toothbrushig With Children's or Regular Toothpastes N/A
Completed NCT04941196 - Bioequivalence Study of Anplag® 90mg (Ticagrelor) Tablet & Brilinta® 90 mg (Ticagrelor) Tablet in Healthy Adult Male Pakistani Subjects Under Fasting Condition Phase 1
Completed NCT05541094 - Study of Vitamin D Fortification of Milk and Oil
Completed NCT03728868 - Tolerability and Risk of Adverse Events With a Probiotic Supplement N/A
Recruiting NCT04513782 - The Contributions of Age Related Changes in the Sound Localization Pathway to Central Hearing Loss
Completed NCT05637060 - Bioequivalence Study of Rosuvastatin Tablet N/A
Not yet recruiting NCT05110885 - Public AttitudesTowards SMA and DMD Awareness, Newborn and Carrier Screening and Physiotherapy Practices
Completed NCT01134978 - Neural Mechanisms of the Contextual Interference Effect: A fNIRs and EEG Study Phase 1
Completed NCT06137534 - Upper Extremity Pattern Exercises and Respiratory Functions N/A
Completed NCT04873570 - Bioequivalence Study of Mofest® 400mg (Moxifloxacin) Tablet With Avelox® 400mg (Moxifloxacin) Tablet in Healthy Pakistani Subjects Phase 1
Enrolling by invitation NCT01872091 - Analysis of Neuromuscular, Circulatory and Biomechanical Responses After Cryotherapy N/A
Completed NCT01872117 - Assessment of Temperature by Infrared Thermography and Blood Conduction Velocity by Doppler After Applying Shortwave Diathermy and Microwave - Correlations With Cardiovascular and Hemodynamic Parameters N/A
Completed NCT02409836 - A Study to Assess the Ingestion of Dentifrice by Children N/A
Recruiting NCT05358561 - Postprandial Glucose, Insulin and Subjective Saturation Response in Healthy Individuals N/A