Healthy Individuals Clinical Trial
Over 60% of crops in Israel are grown in recycled treated waste water. This study aims to determine whether minute quantities of drugs such as Carbamazepine can be found in individuals who ingest vegetables grown in waste water.
40 healthy volunteers will undergo a food frequency questionnaire and ask to undergo a daily
food diary.They will also be asked about drug exposure.
At baseline they will provide a urine and hair sample to determine presence of
pharmaceuticals.
They will then undergo a crossover trial wih one week exposure to vegetables grown in
recycled waste water or fresh water, with a three day wash out period. Participants will be
asked to ingest a minimal amount of lettuce, carrots, peppers, tomatoes and lettuce during
the study period.
During this period questionnaires will continue and urine samples will be collected every
three days. The first compound to be tested will be carbamazepine, as it is stable in water.
It is important to note that vegetables provided to the participants are available in regular
grocery stores.
Participants will be asked to drink bottled water throughout the study period . A sample of
their home drinking water will also be tested for Carbamazepine as will a sample of the
vegetables they consume.
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