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Study for Cognitive and Genetic Characterization of a 45-65 Years Old Population

Healthy Individuals Clinical Trial

Official title:
Cross-sectional Study for Cognitive and Genetic Characterization of a 45-65 Years Old Population

Clinical Trial Summary

Before Alzheimer's disease (AD) clinical symptoms appear, there is a long period when changes in the brain occur. In this long asymptomatic period or preclinical phase, studies with populations at risk of developing AD have shown cognitive differences compared to control groups without such risk. There is a need for short, sensitive, easily administered, reproducible, non-expensive and independent of socio-demographic influences tests enabling the detection of pre-symptomatic variations in memory, when the memory decline is still within a normal range. Study main hypothesis: When evaluated with high-demanding tests of memory and executive function, the cognitive performance of cognitive healthy people aged between 45 and 65 and, extensively, to a group of up to 75 years, will vary significantly depending on clinical, socio-demographic and genetic features

Clinical Trial Description

The purpose of Study 45-65 is to assess if: - Endogenous factors (clinical history, risk factors, genetic factors APOE4, etc…), exogenous (socio-demographic, ambient and lifestyle variables) and cognitive reserve (including bilingualism) influence cognitive performance. - New and/or updated tests translated and validated in Spanish and Catalan when needed, will provide accurate and sensitive measurements of the variability of cognitive performance in this target population, representative of the preclinical phase of Alzheimer's disease. An optional visit is offered to study participants that includes: cerebral magnetic resonance, vascular ultrasound and olfactory testing. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01835717
Study type Observational
Source Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Contact
Status Completed
Phase
Start date April 2013
Completion date December 31, 2020
View Details
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