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Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Activity of Beta-receptors in Healthy Volunteers

Health, Subjective Clinical Trial

Official title:
Effect of Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Binding Activity of Beta-receptors in Healthy Volunteers

Clinical Trial Summary

Interventional open-labeled study in parallel groups is aimed to evaluate changes of beta receptors in healthy volunteers under the influence of inhaled metacholine, long-acting anticholinergics and beta-agonists using modified radioligand method.

Clinical Trial Description

Long-acting beta2-agonists and anticholinergics are main drugs in therapy of chronic obstructive pulmonary disease . Beta-agonists exert their bronchodilatory effects via β2 adrenoceptors located on airway smooth muscle cells. Anticholinergics block mainly M3-cholinoreceptors located in the airways, thus inhibiting bronchoconstriction. Metacholine blocks M2-cholinoreceptors thus inducing bronchoconstriction. It is known, that muscarine and beta-receptors interact with each other, but the detailed mechanism is unknown. For evaluating the binding activity of beta-receptors after inhalation of these drugs the modified radioligand method was used. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04137029
Study type Interventional
Source Federal State Budgetary Institution, Pulmonology Scientific Research Institute
Contact Kirill A Zykov, Prof
Phone +79257729462
Email kirillaz@inbox.ru
Status Recruiting
Phase N/A
Start date April 24, 2019
Completion date October 2020
View Details
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