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Bronchial Hyperreactivity clinical trials

View clinical trials related to Bronchial Hyperreactivity.

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NCT ID: NCT06110481 Recruiting - Clinical trials for Bronchopulmonary Dysplasia

Reversibility of Bronchial Obstruction in Children Born Preterm

Start date: April 1, 2021
Phase:
Study type: Observational

This observational study aims to compare responses to different, commonly used inhaled bronchodilators in children born preterm with bronchial obstruction at spirometry. All children were diagnosed with Chronic Lung Disease of Immaturity (CLDI). The main questions are: - Is any inhaled bronchodilator or their combination generally superior in children with CLDI when assessing the reversibility of bronchial obstruction? - Is there an individual difference in the effect of betamimetic, anticholinergic or their combination between children with CLDI? Participants will: - Come to our clinic in a stable state without acute infection and they will be randomly assigned to the first inhaled bronchodilator. - They will then perform a spirometry test before and after the inhalation of the drug. - This visit will repeat 3 times, each with a different bronchodilator (beta2agonist, anticholinergic and their combination).

NCT ID: NCT06034145 Not yet recruiting - Clinical trials for Bronchial Hyperreactivity

Methacholine Challenge Testing: Comparison of FEV1 and IOS Parameters in Adult Asthma Patients

Start date: November 1, 2023
Phase:
Study type: Observational

A classic methacholine challenge test is considered positive when forced expiratory volumen after one second (FEV1) decrease 20%. Impulse oscillometry (IOS) measures airway resistance and reactance, and seems more sensitive to changes in small airways. In adult asthma patients, we compare methacholine challenge test using both FEV1 and IOS.

NCT ID: NCT06016244 Recruiting - Bronchiolitis Clinical Trials

Safe, Effective and Cost-Effective Oxygen Saturation Targets for Children and Adolescents With Respiratory Distress: a Randomized Controlled Trial

OxyKids
Start date: September 4, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to find out at which lower limit for saturation (amount of oxygen in the blood) we can best give extra oxygen to children that have been admitted for shortness of breath. We hope to accomplish a shorter period of illness for these children and that they can be discharged home earlier. Participants will receive supplemental oxygen if their blood oxygen levels are below 88% or below 92%. After admission, (parents of) participating children will fill out questionnaires. We will compare the two groups on their hospitalization duration and recovery. In other words, is it better to maintain a lower limit of 88% saturation or a lower limit of 92% in children admitted for shortness of breath?

NCT ID: NCT05821868 Completed - Clinical trials for Bronchial Hyperreactivity

Contrasting Dosivent With Plus Flow Vu Spacer in Bronchial Hyperreactivity Participants

Start date: July 1, 2022
Phase: N/A
Study type: Interventional

This study aims to compare the efficacy, as measured by changes in forced expiratory volume in the first second (FEV1) and forced vital capacity (FVC), of salbutamol inhaled with the Dosivent® chamber versus the widely used Aerochamber Plus® Flow-Vu® in participants with a positive bronchodilator testing.

NCT ID: NCT05618769 Recruiting - Smoking Cessation Clinical Trials

Towards Life-Long Healthy Lungs: A Multidisciplinary Follow-up Framework for Preterm Infants

LONG LOVE
Start date: July 18, 2022
Phase: N/A
Study type: Interventional

Approximately 8% of all births occur between 30-36 weeks of gestation ('moderate-late' prematurity). Respiratory tract infections (RTI) and wheezing illnesses disproportionally affect preterm infants resulting in a 1.5-2 fold higher hospitalisation rate during the first years of life compared to term born children. Besides prematurity, several other postnatal modifiable influencing factors are associated with increased risk of respiratory morbidity and impaired pulmonary development. These factors include RTI, rapid weight gain, air pollution, tobacco smoke exposition, vitamin D deficiency, maternal stress and antibiotic usage. The investigators hypothesize that a follow-up program aiming at prevention of modifiable influencing factors can reduce respiratory morbidity in moderate and late prematurity. Objectives: To reduce respiratory disease burden in moderate-late preterm infants in the first 18 months of life

NCT ID: NCT04168554 Not yet recruiting - Asthma Clinical Trials

Telemedicine in the Generals Practitioners Office

Start date: December 2019
Phase:
Study type: Observational

Pediatrician does physical examination through telemedicine and in real life to see whether the telemedicine consultation corresponds with the real life examination. Goal is to determine: 1. Check practical feasability 2. Check whether there are no great objections for a larger study (ie. in case telemedicine consultation is much more unreliable to do a physical examination a larger study is deemed unsafe)

NCT ID: NCT04137029 Recruiting - Health, Subjective Clinical Trials

Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Activity of Beta-receptors in Healthy Volunteers

Start date: April 24, 2019
Phase: N/A
Study type: Interventional

Interventional open-labeled study in parallel groups is aimed to evaluate changes of beta receptors in healthy volunteers under the influence of inhaled metacholine, long-acting anticholinergics and beta-agonists using modified radioligand method.

NCT ID: NCT03421730 Completed - Wheezing Clinical Trials

A Study of the Pharmacokinetics, Safety and Tolerability of Single Doses of VR647 Inhalation Suspension Administered Using the VR647 Inhalation System in Children With Wheezing, Reactive Airway Disease or Mild Asthma

Start date: December 18, 2017
Phase: Phase 1
Study type: Interventional

The primary objective of this study is to evaluate budesonide levels in the blood following inhalation of single doses of VR647 Inhalation Suspension in children with wheezing, reactive airway disease or mild asthma using a nebulizer, the VR647 Inhalation System. Secondary objectives include the evaluation of the safety and tolerability of VR647 Inhalation Suspension administered using the VR647 Inhalation System. The study consists of four visits; a screening visit (Visit 1), two dosing days (Visits 2 and 3) and a follow-up visit (Visit 4). On each dosing day a single dose of treatment will be administered. Treatment allocation at Visits 2 and 3 is determined by a balanced incomplete block design.

NCT ID: NCT03392363 Completed - Pneumonia Clinical Trials

Diagnosing Respiratory Disease in Children Using Cough Sounds 2

SMARTCOUGH-C-2
Start date: January 5, 2018
Phase:
Study type: Observational

The purpose of this prospective study is to evaluate the efficacy of the ResAppDx software application in the diagnosis of childhood acute respiratory disease, including pneumonia, bronchiolitis, asthma/reactive airways disease, croup, lower respiratory tract disease (LRTD), viral lower respiratory tract infection (vLRTI), and upper respiratory tract disease (URTD).

NCT ID: NCT03321877 Completed - Asthma Clinical Trials

Down-titration of Steroids in Patients With Difficult Asthma With no Bronchial Hyperreactivity

DOSIS
Start date: October 1, 2016
Phase: N/A
Study type: Interventional

An 8 week 'real-life' inhaled corticosteroid (ICS) dose reduction study in patients with severe asthma without evidence of bronchial hyperactivity.