Clinical Trials Logo
  1. Home
  2. Halitosis
  3. NCT03996044

Comparative Study Between Photodynamic Therapy With Urucum and LED and Probiotics in Halitosis Reduction

Halitosis Clinical Trial

Official title:
Comparative Study Between Photodynamic Therapy Using Urucum + LED and Probiotics in Halitosis Reduction - Controlled Clinical Trial

Clinical Trial Summary

Introduction: Halitosis is a term that defines any foul odor emanating from the oral cavity. The origin may be local or systemic. The aim of the proposed project is to determine whether treatment with antimicrobial photodynamic therapy (aPDT) and treatment with probiotics are effective at eliminating halitosis. Methods and analysis: Fifty-two patients from 18 to 25 years old with a diagnosis of halitosis (H2S≥112 ppb determined by gas chromatography) will be randomly allocated to four groups (n=13) who will receive different treatments: Group 1 - treatment with teeth brushing, dental floss and tongue scraper; Group 2 - brushing, dental floss and aPDT; Group 3 - brushing, dental floss and probiotics; Group 4 - brushing, flossing, aPDT and probiotics. The results of the halimeter testing will be compared before, immediately after, seven days and thirty days after treatment. The microbiological analysis of the coated tongue will be performed at these same times. The quantitative analysis will be conducted using real-time PCRq. The normality of the data will be determined using the Shapiro-Wilk test. Data with normal distribution will be analyzed using analysis of variance (ANOVA). Non-parametric data will be analyzed using the Kruskal-Wallis test. The Wilcoxon test will be used to analyze the results of each treatment at the different evaluation periods. Ethics and dissemination: This study has been approved by the Ethics Committee of UNINOVE under process number 3.669.442. Results will be published in peer-reviewed journals and will be presented at national and international conferences.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03996044
Study type Interventional
Source University of Nove de Julho
Contact
Status Completed
Phase Phase 1
Start date January 20, 2021
Completion date November 30, 2021
View Details
See also
  Status Clinical Trial Phase
Completed NCT04279106 - Effect of Single Rinsing With Three Different Types of Mouthwash on VSC Levels in Morning Breath N/A
Completed NCT04914208 - Effect of Wearing Face Masks on Salivary Parameters and Halitosis N/A
Completed NCT05413382 - Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis) N/A
Completed NCT05524948 - A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis N/A
Completed NCT02689297 - Three Different Oral Hygiene Regimes on Three Volatile Sulfur Compounds Phase 4
Completed NCT02113137 - Oral Hygiene Procedures on Reduction of Oral Malodor Phase 4
Completed NCT01046812 - Halitosis Devised Questionnaire Evaluating a New Treatment N/A
Withdrawn NCT02665780 - Assessing the Effect of Periodontal Debridement, Tongue Cleaning and Mouth Rinsing for the Treatment of Oral Malodour N/A
Completed NCT01948349 - Impact of Bracket Design and Oral Hygiene Maintenance on Halitosis in the Orthodontic Patient N/A
Recruiting NCT02007993 - Photodynamic Therapy in Adolescents Halitosis N/A
Completed NCT01269957 - Halitosis and Mouth Breathing in Children N/A
Completed NCT04632004 - Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health N/A
Completed NCT04998617 - Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis N/A
Completed NCT01139073 - A New Portable Monitor for Measuring Odorous Compounds in Oral, Exhaled and Nasal Air N/A
Not yet recruiting NCT00875927 - Effects of Breezy Candy on Halitosis Phase 1/Phase 2
Completed NCT03196648 - Randomized Trial of a Gum Health Formulation N/A
Recruiting NCT03346460 - Effect of Photodymamic Therapy With Urucum and LED in the Reduction of Halitosis Phase 2
Completed NCT03468595 - Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis N/A
Completed NCT02794766 - Inulin and S. Salivarius Reduce Halitosis Phase 2
Completed NCT02628938 - Effect of Miswak and Miswak Extract on Oral Malodor Phase 2