Effect of Photodymamic Therapy With Urucum & LED in the Reduction of

Status Recruiting

Clinical Trial Summary

Halitosis, also known as bad breath, is a term used to define an unpleasant and foul odor that emanates from the mouth and may have local or systemic origin. This project aims to observe the presence of halitosis and to verify if the treatment with antimicrobial photodynamic therapy (aPDT) is effective against it. The investigators will select 45 students or UNINOVE employees, from 18 to 25 years old, with a diagnosis of halitosis, presenting sulfite (SH2) ≥ 112 ppb on gas chromatography. Patients will be randomly divided into 3 groups of 15, which will receive different treatments: Group 1: treatment with tongue scraper; Group 2: aPDT applied in the back region and middle third of the tongue; Group 3: combined treatment of tongue scraper and aPDT. For the aPDT we will use urucum manipulated in the concentration of 20% (Fórmula e Ação®) in spray, to be applied in sufficient quantity to cover the middle third and back of the tongue (5 sprinkles) for 5 minutes for incubation, associated with a LED (Valo Cordless Ultradent®). 6 points will be irradiated on the back of the tongue with a distance of 1 cm between the points, considering the halo of light scattering and effectiveness of aPDT. The apparatus shall be precalibrated at wavelength 440-480nm for 60 seconds per point, irradiance of 450mW/cm and the light shall be irradiated so that a halo of 2cm diameter is formed per point. The results of the halimetry will be compared before and immediately after the treatment, besides the microbiological analysis of the tongue coating, before and after the treatment. The normality of the data will be measured using the Shapiro-Wilk test, and in the case of normality the Variance Analysis (ANOVA) test will be applied, and in the case of non-parametric data, the Kruskal-Wallis test will be used. To analyze the results of each treatment in both periods of the study, the Wilcoxon test will be used.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Halitosis

Clinical Trial Details

NCT number	NCT03346460
Study type	Interventional
Source	University of Nove de Julho
Contact	Marcela LL Gonçalves, MS
Phone	+55113385-9010
Email	marcelalleal@hotmail.com
Status	Recruiting
Phase	Phase 2
Start date	March 5, 2018
Completion date	December 5, 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04279106` - Effect of Single Rinsing With Three Different Types of Mouthwash on VSC Levels in Morning Breath	N/A
Completed	`NCT04914208` - Effect of Wearing Face Masks on Salivary Parameters and Halitosis	N/A
Completed	`NCT05413382` - Effect of an Investigational Lozenge (Biofresh® 4plus) Versus Placebo Control on Oral Malodor (Intra-Oral Halitosis)	N/A
Completed	`NCT05524948` - A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis	N/A
Completed	`NCT02113137` - Oral Hygiene Procedures on Reduction of Oral Malodor	Phase 4
Completed	`NCT02689297` - Three Different Oral Hygiene Regimes on Three Volatile Sulfur Compounds	Phase 4
Completed	`NCT01046812` - Halitosis Devised Questionnaire Evaluating a New Treatment	N/A
Withdrawn	`NCT02665780` - Assessing the Effect of Periodontal Debridement, Tongue Cleaning and Mouth Rinsing for the Treatment of Oral Malodour	N/A
Completed	`NCT01948349` - Impact of Bracket Design and Oral Hygiene Maintenance on Halitosis in the Orthodontic Patient	N/A
Recruiting	`NCT02007993` - Photodynamic Therapy in Adolescents Halitosis	N/A
Completed	`NCT01269957` - Halitosis and Mouth Breathing in Children	N/A
Completed	`NCT04632004` - Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health	N/A
Completed	`NCT04998617` - Effects of Curcumin-containing Toothpaste on Dental Biofilm and Associated Oral Halitosis	N/A
Not yet recruiting	`NCT00875927` - Effects of Breezy Candy on Halitosis	Phase 1/Phase 2
Completed	`NCT01139073` - A New Portable Monitor for Measuring Odorous Compounds in Oral, Exhaled and Nasal Air	N/A
Completed	`NCT03196648` - Randomized Trial of a Gum Health Formulation	N/A
Completed	`NCT03468595` - Clinical Evaluation of Some Local Antimicrobial Agents' Adjunctive Effects On Periodontal Parameters and Halitosis	N/A
Completed	`NCT02794766` - Inulin and S. Salivarius Reduce Halitosis	Phase 2
Completed	`NCT02628938` - Effect of Miswak and Miswak Extract on Oral Malodor	Phase 2
Not yet recruiting	`NCT01747226` - Effect of Mouth Rinses in Oral Malodor	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

Effect of Photodymamic Therapy With Urucum and LED in the Reduction of Halitosis

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms